This chapter presents a general overview on computational models of the heart. It focuses
on mathematical modeling of the various physiological aspects involved in cardiac function …

Abstract Systems biology has introduced new paradigms in science by switching from a
reductionist point of view to a more integrative approach toward the study of systems. As …

This chapter describes a possible implementation of a comprehensive model of heart
function. The presentation follows the same organization of the previous chapter. We first …

A computational framework is presented for integrating the electrical, mechanical and
biochemical functions of the heart. Finite element techniques are used to solve the large …

The simulation of cardiac electrical function is an example of a successful integrative
multiscale modelling approach that is directly relevant to human disease. Today we stand at …

Mathematical modeling of the human heart and its function can expand our understanding of
various cardiac diseases, which remain the most common cause of death in the developed …

Computational methods for modeling of patient-specific mechanics of the heart and the
circulatory system are developed. The 3-dimensionally resolved heart is coupled to a …

As decisions in cardiology increasingly rely on non-invasive methods, fast and precise
image analysis tools have become a crucial component of the clinical workflow. Especially …

Simulation of cardiac electrical function, and specifically, simulation aimed at understanding
the mechanisms of cardiac rhythm disorders, represents an example of a successful …

The goal of clinical cardiology is to obtain an integrated picture of the interacting parameters
of muscle and vessel mechanics, blood circulation and myocardial perfusion, oxygen …