G protein–coupled estrogen receptor (GPER) might be involved in ulcerative colitis (UC), but
the direct effect of GPER on UC is still unclear. We used male C57BL/6 mice to establish the …

Chemotherapy-induced intestinal mucositis (CIM) is a common adverse reaction to
antineoplastic treatment with few appropriate, specific interventions. We aimed to identify the …

Estrogen and its receptors are involved in the pathogenesis of gastrointestinal diseases
such as colitis. However, the role of the membrane estrogen receptor G-protein-coupled …

The intestinal ischemia/reperfusion (I/R) injury is a common clinical event related with high
mortality in patients undergoing surgery or trauma. Estrogen exerts salutary effect on …

Estrogens exert immunomodulatory action in many autoimmune diseases. Accumulating
evidence highlights the meaningful impact of estrogen receptors in physiology and …

Background Diarrhea‐predominant irritable bowel syndrome (IBS‐D) is a functional
gastrointestinal (GI) disorder, which occurs more frequently in women than men. The aim of …

Estrogens play important roles in the development and progression of multiple tumor types.
Accumulating evidence points to the significance of estrogen action not only in tumors of …

The regulatory role of estrogens and nuclear estrogen receptors, ie, estrogen receptor α and
β has been reported in gastrointestinal diseases. However, the contribution of G protein …

Objectives This study aimed to evaluate the therapeutic effects and mechanism of genistein
on dextran sulfate sodium-induced mouse model of ulcerative colitis (UC). Materials and …

Background and Purpose Activation of the human pregnane X receptor (PXR; NR1I2) has
potential therapeutic uses for inflammatory bowel disease (IBD). Imperatorin (IMP), a …