Proteinuria and exposure to eculizumab in atypical hemolytic uremic syndrome
M Ter Avest, H Steenbreker… - Clinical Journal of the …, 2023 - journals.lww.com
Background Eculizumab is a monoclonal antibody for the treatment of atypical hemolytic
uremic syndrome (aHUS). Kidney damage, a common condition in patients with aHUS, may …
uremic syndrome (aHUS). Kidney damage, a common condition in patients with aHUS, may …
Reduced dose maintenance eculizumab in atypical hemolytic uremic syndrome (aHUS): an update on a previous case report
M Ohanian, C Cable, K Halka - Clinical pharmacology: advances …, 2011 - Taylor & Francis
Objective To describe how maintenance eculizumab sustains improved renal function in
severe atypical hemolytic uremic syndrome (aHUS). Case report A previously described 50 …
severe atypical hemolytic uremic syndrome (aHUS). Case report A previously described 50 …
Should eculizumab be discontinued in patients with atypical hemolytic uremic syndrome?
E Rodriguez, C Barrios, MJ Soler - Clinical Kidney Journal, 2017 - academic.oup.com
Atypical hemolytic uremic syndrome (aHUS) is a life-threatening disorder for which prompt
diagnosis and eculizumab treatment is indicated. The time for relapse and patients at risk for …
diagnosis and eculizumab treatment is indicated. The time for relapse and patients at risk for …
Eculizumab treatment in atypical hemolytic uremic syndrome: Correlation between functional complement tests and drug levels
M Cugno, V Capone, S Griffini, E Grovetti… - Journal of …, 2022 - Springer
Background Atypical hemolytic uremic syndrome (aHUS) is characterized by platelet
consumption, hemolysis, and renal injury. Eculizumab, a humanized antibody that blocks …
consumption, hemolysis, and renal injury. Eculizumab, a humanized antibody that blocks …
Outcome of atypical haemolytic uraemic syndrome relapse after eculizumab withdrawal
C Duineveld, R Bouwmeester… - Clinical Kidney …, 2021 - academic.oup.com
Background The introduction of eculizumab has significantly improved the outcome of
patients with atypical haemolytic uraemic syndrome (aHUS). Because of the risk of relapse …
patients with atypical haemolytic uraemic syndrome (aHUS). Because of the risk of relapse …
Proposal for individualized dosing of eculizumab in atypical haemolytic uraemic syndrome: patient friendly and cost-effective
M Ter Avest, RN Bouwmeester… - Nephrology dialysis …, 2023 - academic.oup.com
Background Eculizumab is a lifesaving yet expensive drug for atypical haemolytic uraemic
syndrome (aHUS). Current guidelines advise a fixed-dosing schedule, which can be …
syndrome (aHUS). Current guidelines advise a fixed-dosing schedule, which can be …
[HTML][HTML] Improved renal recovery in patients with atypical hemolytic uremic syndrome following rapid initiation of eculizumab treatment
JV Walle, Y Delmas, G Ardissino, J Wang… - Journal of …, 2017 - Springer
Background Eculizumab is approved for atypical hemolytic uremic syndrome (aHUS).
Guidelines discuss the importance of prompt treatment. We report a post hoc analysis …
Guidelines discuss the importance of prompt treatment. We report a post hoc analysis …
Eculizumab dosing regimen in atypical HUS: possibilities for individualized treatment
E Volokhina, K Wijnsma… - Clinical …, 2017 - Wiley Online Library
Recent studies indicate that eculizumab is often given in excess to atypical hemolytic uremic
syndrome (aHUS) patients. Individualization of treatment is thus highly requested; however …
syndrome (aHUS) patients. Individualization of treatment is thus highly requested; however …
[HTML][HTML] Early eculizumab withdrawal in patients with atypical hemolytic uremic syndrome in native kidneys is safe and cost-effective: results of the CUREiHUS study
RN Bouwmeester, C Duineveld, KL Wijnsma… - Kidney International …, 2023 - Elsevier
Introduction The introduction of eculizumab has improved the outcome in patients with
atypical hemolytic uremic syndrome (aHUS). The optimal treatment strategy is debated …
atypical hemolytic uremic syndrome (aHUS). The optimal treatment strategy is debated …
Insights from the use in clinical practice of eculizumab in adult patients with atypical hemolytic uremic syndrome affecting the native kidneys: an analysis of 19 cases
F Fakhouri, Y Delmas, F Provot, C Barbet… - American journal of …, 2014 - Elsevier
Background Atypical hemolytic uremic syndrome (aHUS) is a devastating form of renal
thrombotic microangiopathy. Despite plasma exchange, the standard treatment of aHUS for …
thrombotic microangiopathy. Despite plasma exchange, the standard treatment of aHUS for …