Connexins are a family of proteins that can form two distinct types of channels:
hemichannels and gap junction channels. Hemichannels are composed of six connexin …

Gap junctions are multimeric membrane protein channels that connect the cytoplasm of one
cell to another. Much information about connexins regards electrophysiology and channel …

Gap-junction hemichannels are composed of six protein subunits (connexins). Undocked
hemichannels contribute to physiological autocrine/paracrine cell signaling, including …

Mutations within connexin50 (Cx50) have been linked to various cataract phenotypes. To
determine the mechanism behind cataract formation we used the paired Xenopus oocyte …

The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells
that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) …

Abstract Connexin46 (Cx46), together with Cx50, forms gap junction channels between lens
fibers and participates in the lens pump-leak system, which is essential for the homeostasis …

The human lens is an avascular organ, and its transparency is dependent on gap junction
(GJ)-mediated microcirculation. Lens GJs are composed of three connexins with Cx46 and …

The avascular lens of the eye is covered anteriorly by an epithelium containing nucleated,
metabolically active cells. This epithelium contains the first lens cells to encounter noxious …

Human connexin46 (hCx46) forms gap junctional channels interconnecting lens fiber cells
and appears to be critical for normal lens function, because hCx46 mutations have been …

Connexin channels help maintain eye lens homeostasis and transparency. The G143R
missense substitution in connexin (Cx) 46 is associated with congenital Coppock cataracts; …