Connexins form gap junction channels that provide a hydrophilic path between cell interiors.
Some connexins, particularly the lens connexins, Cx46 and Cx50 and their orthologs, can …

The cells of most mammalian organs are connected by groups of cell-to-cell channels called
gap junctions. Gap junction channels are made from the connexin (Cx) family of proteins …

Connexin channels play a critical role in maintaining metabolic homeostasis and
transparency of the lens. Mutations in connexin genes are linked to congenital cataracts in …

Gap junctions are composed of proteins called connexins (Cx) and facilitate both ionic and
biochemical modes of intercellular communication. In the lens, Cx46 and Cx50 provide the …

Mutations in Connexin50 (Cx50) cause cataracts in both humans and mice. The mechanism
(s) behind how mutated connexins lead to a variety of cataracts have yet to be fully …

Many human connexin50 (Cx50) mutants have been linked to cataracts including two
carboxyl terminus serine mutants that are known phosphorylation sites in the lens …

The normal function and survival of cells in the avascular lens is facilitated by intercellular
communication through an extensive network of gap junctions formed predominantly by …

The connexins are members of a family of integral membrane proteins that form gap junction
channels between apposed cells and/or hemichannels across the plasma membranes. The …

In the last decade or so, increasing evidences suggest that the mutations of two connexin
genes, GJA3 and GJA8, are directly linked to human congenital cataracts in North and …

Lens fiber connexins, cx50 and cx46 (α3 and α8), belong to a small subset of connexins that
can form functional hemichannels in nonjunctional membranes. Knockout of either cx50 or …