Abstract Connexin 46 (cx46), when expressed in Xenopus oocytes, not only forms typical
gap junction channels between paired cells but also forms open gap junction hemichannels …

Connexin (Cx)-forming channels play essential roles in maintaining lens homeostasis and
transparency. We showed here channel-independent roles of Cx50 in cell–cell adhesion …

A detailed understanding of the mechanisms regulating cell-to-cell communication in the
lens necessitates information about the distribution and density of Cx46 and Cx50 in their …

Gap junction channels formed by connexin 50 (Cx50) are critical for maintenance of lens
transparency. Because the C-terminus of Cx50 can be cleaved post-translationally, we …

Gap junction channels mediate the direct intercellular passage of small ions as well as
larger solutes such as second messengers. A family of proteins called connexins make up …

Cataract is a common disease in the aging population. Gap junction has been considered a
central component in maintaining homeostasis for preventing cataract formation. Gap …

Gap junction channels made of different connexins have distinct permeability to second
messengers, which could affect many cell processes, including lens epithelial cell division …

An N-terminal mutant of connexin46 (T19M) alters a highly conserved threonine and has
been linked to autosomal dominant cataracts. To study the cellular and functional …

Purpose.: To determine the consequences of expression of a novel connexin50 (CX50)
mutant identified in a child with congenital total cataracts. Methods.: The GJA8 gene was …

Gap junctions formed of connexin46 (Cx46) and connexin50 (Cx50) in lens fiber cells are
crucial for maintaining lens transparency. We determined the functional properties of …