Publisher Summary The ocular lens, because of its syncytial properties, has traditionally
attracted researchers interested in the structure and function of gap junctions. Such intense …

Connexins play essential roles in lens homeostasis and development. Here, we identified a
new role for Cx50 that mediates cell-cell adhesion function. Cx50 enhanced the adhesive …

Purpose: Gap junction channels exhibit connexin specific biophysical properties, including
the selective intercellular passage of larger solutes, such as second messengers. Here, we …

purpose. Lens connexins undergo proteolytic cleavage of their C termini during fiber
maturation. Although the functional significance of this is unknown, cleavage has been …

The connexin (Cx) 50, E48K, mutation is associated with a human dominant congenital
cataract; however, the underlying molecular mechanism has not been characterized. The …

In the lens, cell homeostasis and transparency are supported by intercellular communication
facilitated by the channels formed of connexin46 (Cx46) and connexin50 (Cx50). Mutations …

In the vertebrate eye, virtually every cell type is directly coupled to its neighbors by
intercellular channels present in gap junctions. Although these structures share the common …

Lens development and transparency have been hypothesized to depend on intercellular
gap junction channels, consisting of α3 (Cx46) and α8 (Cx50) connexin subunits, to …

Elevated oxidized stress contributes to lens cataracts, and gap junctions play important roles
in maintaining lens transparency. As well as forming gap junctions, connexin (Cx) proteins …

Lens gap junctions (GJs) formed by Cx46 and Cx50 are important to keep lens
transparency. Functional studies on Cx46 and Cx50 GJs showed that the Vj-gating, single …