Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly
driven by the release of extracellular ATP through Cx43 hemichannels. Studying the …

Lens fiber cell gap junctions contain α3 (Cx46) and α8 (Cx50) connexins. To examine the
roles of the two different connexins in lens physiology, we have genetically engineered mice …

Purpose The gap junctions (GJs) mediating direct cell-cell interaction are formed by clusters
of membrane-spanning proteins known as connexins (Cxs). These channels play a key role …

Purpose.: Although many connexin46 (Cx46) mutants have been linked to inherited human
cataracts, there are no adequate animal models for their study. The current experiments …

Mutations in connexin50 (Cx50) cause dominant cataracts in both humans and mice. The
exact mechanisms by which mutations cause these variable phenotypes are poorly …

The differentiation of mouse lens epithelial cells into fiber cells is a useful model for studying
the changes of the electrical properties of gap junction (cell-to-cell) channels that are …

Gap junction channels formed by connexin50 (Cx50) are critical for maintenance of eye lens
transparency. Cleavage of the carboxyl terminus (CT) of Cx50 to produce truncated Cx50 …

Different mutations of α3 connexin (Cx46 or Gja8) andα8 connexin (Cx50 or Gja8), subunits
of lens gap junction channels, cause a variety of cataracts via unknown mechanisms. We …

Abstract While connexin46 (Cx46) and connexin50 (Cx50) are crucial for maintaining lens
transparency and growth, the contributions of a more recently identified lens fiber connexin …

Mutations in gap junctional channels have been linked to certain forms of inherited
congenital cataract (D. Mackay, A. Ionides, V. Berry, A. Moore, S. Bhattacharya, and A …