Mutations in connexin50 (Cx50) cause dominant cataracts in both humans and mice. The
exact mechanisms by which mutations cause these variable phenotypes are poorly …

Connexin (Cxs) hemichannels participate in several physiological and pathological
processes, but the molecular mechanisms that control their gating remain elusive. We aimed …

Gap junction channels formed by α 3 (Cx46) and α 8 (Cx50) connexin provide pathways for
communication between the fiber cells in the normal transparent lens. To determine the …

Cx46 and Cx50 are coexpressed in lens fiber cells where they form fiber-fiber gap junctions.
Recent studies have shown that both proteins play a critical role in maintaining lens …

A G22R point mutation in α8 connexin (Cx50) has been previously shown to cause a severe
cataract by interacting with endogenous wild-type α3 connexin (Cx46) in mouse lenses …

Mutations in gap junctional channels have been linked to certain forms of inherited
congenital cataract (D. Mackay, A. Ionides, V. Berry, A. Moore, S. Bhattacharya, and A …

Connexins are the transmembrane proteins that form gap junctions between adjacent cells.
The function of the diverse connexin molecules is related to their tissue-specific expression …

purpose. To map changes in the structure and function of fiber cell gap junctions that occur
with lens differentiation. methods. Equatorial lens sections were fluorescently labeled with …

purpose. To investigate the effects of reducing connexin (Cx) diversity in the lens when the
amount of connexin protein is nearly constant. methods. Lenses in which the Cx50 coding …

Abstract Background Connexin43 (Cx43) is an integral membrane protein that forms
intercellular channels called gap junctions. Intercellular communication in the eye lens relies …