Colorectal cancer (CRC) is associated with loss of epithelial barrier integrity, which
facilitates the interaction of the immunological microenvironment with the luminal …

Objective Accumulating evidences suggest that immune checkpoints (ICs) inhibit immune
response against cancerous cells and promote tumor cell survival. Up-regulation of ICs in …

Simple Summary One promising avenue for the treatment of colorectal cancer is the
reinvigoration of pre-existing anti-tumor T-cell responses by overcoming inhibitions that …

Antitumor inflammatory response is known to inhibit tumor growth in colorectal carcinoma.
The density and functionality of tumor-infiltrating lymphocytes (TIL) is regulated by the …

Abstract Background Regulatory T (T reg) cells have an immunosuppressive function in
cancer, but the underlying mechanism of immunosuppression in the tumor …

Chronic inflammation drives colitis-associated colorectal cancer (CAC) in inflammatory
bowel disease (IBD). FoxP3+ regulatory T cells (Treg) coexpressing the Th17-related …

Enrichment of regulatory T cells (Tregs) in the tumour microenvironment (TME) has been
recognized as one of the major factors in the initiation and development of resistance to …

Immune infiltration has been correlated with survival of patients with colorectal cancer. In this
issue, Ziegler et al. reveal complex and unexpected connections between loss of STAT3 …

Increased tumor infiltrating lymphocytes (TIL) are associated with improved patient
responses to immunotherapy. As a result, there is interest in enhancing lymphocyte …

Purpose This study attempted to reveal the prognostic impact of microsatellite instability-high
(MSI-H) colon cancer with tumor-infiltrating immune cells (TIICs) and immune checkpoint …