Purpose PIK3CA mutation or overexpression is associated with immunotherapy resistance
in multiple cancer types, but is also paradoxically associated with benefit of COX-2 inhibition …

Aim: To elucidate the epigenetic alterations behind the upregulation of immune checkpoints
and T cell exhaustion markers in colorectal cancer (CRC) patients. Materials & methods …

Disturbed balance between immune surveillance and tolerance may lead to poor clinical
outcomes in some malignancies. In paired analyses of adenocarcinoma and normal mucosa …

Colorectal cancer (CRC) is classified as the third leading cancer globally and one of the
major causes of morbidity and mortality around the world. The interaction of the immune …

Simple Summary The poor prognosis outcome of patients with KRAS mutations (KRAS mut)
was correlated with an immunosuppressive tumor microenvironment (TME). At the gene …

Background Cytotoxic CD8+ T cell-mediated response is the most important arm of adaptive
immunity, which dictates the capacity of the host immune response in eradicating tumor …

Abstract Absent in Melanoma 2 (AIM2) is a member of the HIN-200 family of hematopoietic,
IFN-inducible, nuclear proteins, associated with both, infection defense and tumor …

Background Macrophage infiltration is crucial for colorectal cancer (CRC) immunotherapy.
Detailed classification of macrophage subsets will facilitate the selection of patients suitable …

Immunotherapy has allowed major advances in oncology in the past years, in particular with
the development of immune checkpoint inhibitors, but the clinical benefits are still limited …

Background Regulatory T cells (Treg) are an integral part of the tumor immune tolerance.
Carcinoma-associated fibroblasts (CAFs) is a pivotal driver for accumulation of Treg cells in …