The immunosuppressive tumor microenvironment limits the application of adoptive
immunotherapy for solid tumors. Hypoxia is closely associated with the formation of the …

Hypoxia is a common phenomenon in solid tumors and is strongly linked to hallmarks of
cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type …

Regulatory T cells (Tregs) can be antitumorigenic or pro-tumorigenic in colorectal cancer
(CRC) depending on the presence of different Treg subsets with various …

Targeting the immune system as a major therapeutic modality for the treatment of cancer has
finally come of age, with immune checkpoint inhibitors leading the way. Better …

The trouble with TRIBbles: TRIB3 blocks CD8 T cell homing to colorectal cancers | Science
Immunology news careers commentary Journals Science Science brought to you byGoogle …

Inflammation is the main driver of the tumor initiation and progression in colitis-associated
colorectal cancer (CAC). Recent findings have indicated that the signal transducer and …

Hypoxia occurs in physiological and pathological conditions. T cells experience hypoxia in
pathological and physiological conditions as well as in lymphoid organs. Indeed, hypoxia …

Cancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell
population in the tumour microenvironment, serving diverse functions in tumour progression …

Gastrointestinal (GI) cancers remain a significant global health burden, accounting for a
substantial number of cases and deaths. Regrettably, the inadequacy of dependable …

With the broad application of cancer immunotherapies such as immune checkpoint inhibitors
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …