The identification of several mutations causing familial forms of Parkinson's disease (PD)
has led to the creation of multiple lines of mice expressing similar genetic alterations. These …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder,
affecting more than 1% of the population over age 60. The most common feature of PD is a …

Parkinson's disease (PD) is a progressive neurological disorder characterised by aberrant
accumulation of insoluble proteins, including alpha‐synuclein, and a loss of dopaminergic …

Parkinson's disease (PD) is a progressive, neurodegenerative disorder of unknown etiology,
although a complex interaction between environmental and genetic factors has been …

Genetic mouse models based on α-synuclein overexpression are particularly compelling
because abnormal accumulation of α-synuclein occurs in sporadic Parkinson's disease …

Most cases of Parkinson′ s disease (PD) are sporadic. When choosing an animal model for
idiopathic PD, one must consider the extent of similarity or divergence between the …

Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The
etiology of PD is likely due, in part, to combinations of genetic susceptibilities and …

To date, a truly representative animal model of Parkinson disease (PD) remains a critical
unmet need. Although toxin-induced PD models have served many useful purposes, they …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized
pathologically by the degeneration of nigrostriatal pathway dopaminergic neurons and other …

Prior to the discovery of genes associated with familial forms of Parkinson's disease, animal
models of Parkinson's disease mainly consisted of toxin models based exclusively on the …