Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease
CR Overk, CM Kelley, EJ Mufson - Neurobiology of disease, 2009 - Elsevier
The triple transgenic mouse (3xTgAD), harboring human APPSwe, PS1M146V and
TauP301L genes, develops age-dependent forebrain intraneuronal Aβ and tau as well as …
TauP301L genes, develops age-dependent forebrain intraneuronal Aβ and tau as well as …
Staging of Alzheimer′ s Pathology in Triple Transgenic Mice: A Light and Electron Microscopic Analysis
KJ Oh, SE Perez, S Lagalwar, L Vana… - International journal …, 2010 - Wiley Online Library
The age‐related pathological cascade underlying intraneuronal tau formation in 3xTg‐AD
mice, which harbor the human APPSwe, PS1M126V, and TauP301L gene mutations …
mice, which harbor the human APPSwe, PS1M126V, and TauP301L gene mutations …
Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease
There is pivotal evidence that tau pathology can be triggered by amyloid-β (Aβ) pathology in
experimental systems. On the other side, studies on human brain specimen have elucidated …
experimental systems. On the other side, studies on human brain specimen have elucidated …
[HTML][HTML] Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice
MA Mastrangelo, WJ Bowers - BMC neuroscience, 2008 - Springer
Background Several transgenic animal models genetically predisposed to develop
Alzheimer's disease (AD)-like pathology have been engineered to facilitate the study of …
Alzheimer's disease (AD)-like pathology have been engineered to facilitate the study of …
[HTML][HTML] Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease
D Ciavardelli, E Silvestri, A Del Viscovo, M Bomba… - Cell death & …, 2010 - nature.com
The triple-transgenic Alzheimer (3× Tg-AD) mouse expresses mutant PS1 M146V, APP swe,
and tau P301L transgenes and progressively develops plaques and neurofibrillary tangles …
and tau P301L transgenes and progressively develops plaques and neurofibrillary tangles …
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model
C Hirata-Fukae, HF Li, HS Hoe, AJ Gray, SS Minami… - Brain research, 2008 - Elsevier
Epidemiological studies indicate that women have a higher risk of Alzheimer's disease (AD)
even after adjustment for age. Though transgenic mouse models of AD develop AD-related …
even after adjustment for age. Though transgenic mouse models of AD develop AD-related …
Triple‐transgenic Alzheimer's disease mice exhibit region‐specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology
MK Desai, KL Sudol, MC Janelsins, MA Mastrangelo… - Glia, 2009 - Wiley Online Library
Alzheimer's disease (AD) is a progressively debilitating brain disorder pathologically defined
by extracellular amyloid plaques, intraneuronal neurofibrillary tangles, and synaptic …
by extracellular amyloid plaques, intraneuronal neurofibrillary tangles, and synaptic …
Temporal and regional progression of Alzheimer's disease‐like pathology in 3xTg‐AD mice
R Belfiore, A Rodin, E Ferreira, R Velazquez… - Aging cell, 2019 - Wiley Online Library
Accumulation of amyloid‐β (Aβ) and fibrillary tangles, as well as neuroinflammation and
memory loss, are hallmarks of Alzheimer's disease (AD). After almost 15 years from their …
memory loss, are hallmarks of Alzheimer's disease (AD). After almost 15 years from their …
Profile for amyloid-β and tau expression in primary cortical cultures from 3xTg-AD mice
C Vale, E Alonso, JA Rubiolo, MR Vieytes… - Cellular and molecular …, 2010 - Springer
Advances in transgenic technology as well as in the genetics of Alzheimer disease (AD)
have allowed the establishment of animal models that reproduce amyloid-beta plaques and …
have allowed the establishment of animal models that reproduce amyloid-beta plaques and …
Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease
JM Hunter, WJ Bowers, CL Maarouf… - Journal of …, 2011 - content.iospress.com
Transgenic (Tg) mouse models of Alzheimer's disease (AD) have been genetically altered
with human familial AD genes driven by powerful promoters. However, a Tg model must …
with human familial AD genes driven by powerful promoters. However, a Tg model must …