Cyclooxygenase (COX)-2 levels are elevated in several types of human cancer tissues.
Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the COX-1 and …

Several types of human tumors overexpress cyclooxygenase (COX)-2 but not COX-1, and
gene knockout transfection experiments demonstrate a central role of COX-2 in …

On the basis of epidemiological observations that nonsteroidal anti-inflammatory drugs
reduce the risk of esophageal carcinoma, we studied the expression of cyclooxygenase-2 …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Several studies indicate that the use of non-steroidal anti-inflammatory drugs (NSAIDs) may
reduce the risk of esophageal cancer. The best known function of NSAIDs action is to block …

Abstract Background and Objectives Epidemiological studies have suggested that the
regular use of nonsteroidal antiinflammatory drugs, which inhibit cyclooxygenase (COX) …

Cyclooxygenase (COX) consists of two isozymes, COX-1 and COX-2. The roles of these
isozymes in the gastrointestinal tract are unknown. We investigated messenger RNA …

The two isoforms cyclooxygenase-1 and-2 catalyze the initial step in the formation of
prostaglandins in a variety of pathophysiological processes. More recently their role in …

Abstract Cyclooxygenase-2 (COX-2), the enzyme that converts arachidonic acid to
prostaglandin H 2, is expressed in normal brain and kidney, activated macrophages …

Epidemiological studies indicate that the use of aspirin decreases incidence of and mortality
from gastrointestinal cancers. A major target of aspirin and other nonsteroid anti …