Hematopoietic stem cell (HSC) attrition is considered the key event underlying progressive
BM failure (BMF) in Fanconi anemia (FA), the most frequent inherited BMF disorder in …

Bone marrow failure (BMF) in Fanconi anemia (FA) patients results from dysfunctional
hematopoietic stem and progenitor cells (HSPCs). To identify determinants of BMF, we …

Fanconi anemia (FA), an inherited syndrome that associates bone marrow failure, cancer
predisposition, and genetic instability, is characterized by an overproduction of the …

An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi
anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive …

Fanconi anemia (FA) is the most common inherited bone marrow failure syndrome. FA
patients develop bone marrow failure during the first decade of life due to attrition of …

Fanconi anemia (FA) is the most common inherited bone marrow failure syndrome. FA
patients suffer to varying degrees from a heterogeneous range of developmental defects …

Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone
marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater …

Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by
bone marrow failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). Eight FA …

Within regenerating tissues, aging is characterized by a progressive general deterioration of
organ function, thought to be driven by the gradual depletion of functional adult stem cells …

Our mechanistic understanding of Fanconi anemia (FA) pathway function in hematopoietic
stem and progenitor cells (HSPCs) owes much to their role in experimentally induced DNA …