Blockade of β-adrenergic receptors by propranolol disrupts reconsolidation of drug memory and attenuates heroin seeking

L Chen, S Huang, C Yang, F Wu, Q Zheng… - Frontiers in …, 2021 - frontiersin.org
Persistent traces of drug reward memories contribute to intense craving and often trigger
relapse. A number of pharmacological interventions on drug-associated memories have …

Reactivating addiction-related memories under propranolol to reduce craving: a pilot randomized controlled trial

M Lonergan, D Saumier, J Tremblay, B Kieffer… - Journal of behavior …, 2016 - Elsevier
Background The reconsolidation blocker propranolol abolishes alcohol and drug-seeking
behavior in rodents and attenuates conditioned emotional responses to drug-cues in …

Inhibition of β-adrenergic receptors induces a persistent deficit in retrieval of a cocaine-associated memory providing protection against reinstatement

JM Otis, D Mueller - Neuropsychopharmacology, 2011 - nature.com
Drug-seeking behavior is maintained by encounters with drug-associated cues. Preventing
retrieval of drug-associated memories that these cues provoke would therefore limit relapse …

Modulating reconsolidation and extinction to regulate drug reward memory

JF Liu, J Tian, JX Li - European Journal of Neuroscience, 2019 - Wiley Online Library
Drug addiction is an aberrant memory that shares the same memory processes as other
memories. Brief exposure to drug‐associated cues could result in reconsolidation, a …

Effects of β-adrenergic receptor blockade on drug-related memory reconsolidation in abstinent heroin addicts

LY Zhao, LL Sun, J Shi, P Li, Y Zhang, L Lu - Drug and alcohol …, 2011 - Elsevier
RATIONALE AND OBJECTIVE: The reactivation of a consolidated memory can return it to a
labile state, a process referred to as reconsolidation. A previous study showed that oral …

Inhibition of hippocampal β-adrenergic receptors impairs retrieval but not reconsolidation of cocaine-associated memory and prevents subsequent reinstatement

JM Otis, MK Fitzgerald, D Mueller - Neuropsychopharmacology, 2014 - nature.com
Retrieval of drug-associated memories is critical for maintaining addictive behaviors, as
presentation of drug-associated cues can elicit drug seeking and relapse. Recently, we and …

Differential effects of propranolol on conditioned hyperactivity and locomotor sensitization induced by morphine in rats

S Wei, X Li - Scientific Reports, 2014 - nature.com
According to memory reconsolidation theory, when long-term memory is reactivated by
relevant clues, the memory traces become labile, which can be altered by pharmacological …

Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference

L Font, CL Cunningham - Pharmacology Biochemistry and Behavior, 2012 - Elsevier
The reconsolidation hypothesis posits that established emotional memories, when
reactivated, become labile and susceptible to disruption. Post-retrieval injection of …

Disruption of long-term alcohol-related memory reconsolidation: role of β-adrenoceptors and NMDA receptors

JA Wouda, L Diergaarde, D Riga, Y Mourik… - Frontiers in behavioral …, 2010 - frontiersin.org
Disrupting reconsolidation of drug-related memories may be effective in reducing the
incidence of relapse. In the current study we examine whether alcohol-related memories are …

β1-adrenoceptor in the central amygdala is required for unconditioned stimulus-induced drug memory reconsolidation

H Zhu, Y Zhou, Z Liu, X Chen, Y Li… - International Journal of …, 2018 - academic.oup.com
Background Drug memories become labile and reconsolidated after retrieval by
presentation of environmental cues (conditioned stimulus) or drugs (unconditioned …