Background: Primary hyperparathyroidism (pHPT) related hypercalcaemia is considered to
represent a risk factor for the development of pancreatitis. We therefore explored whether …

The discovery of the calcium-sensing receptor (CaR) 15 yr ago was rapidly followed by the
development of drugs modulating its activity, the so-called calcimimetics (increasing the …

Context: The autosomal dominantly inherited condition familial hypocalciuric hypercalcemia
(FHH) is characterized by elevated plasma calcium levels, relative or absolute hypocalciuria …

The calcimimetic cinacalcet increases the sensitivity of the parathyroid calcium-sensing
receptor to calcium and therefore should produce a decrease in the set point of the …

Clinical studies have been performed to determine the effect of cinacalcet HCl (cinacalcet),
an allosteric modulator of the calcium-sensing receptor (CaR), on primary …

Familial hypocalciuric hypercalcemia (FHH) is a benign disorder with heterozygous
inactivating mutations in the calcium-sensing receptor (CASR) gene. The present study …

Association of decreased calcium-sensing receptor expression with proliferation of
parathyroid cells in secondary hyperparathyroidism. Background The down-regulation of …

Background: Familial hypocalciuric hypercalcemia (FHH) is usually characterized by
asymptomatic hypercalcemia, hypocalciuria and normal PTH. The diagnosis of FHH is often …

OBJECTIVES:: The calcium-sensing receptor (CASR) is critical for maintenance of blood
calcium in a narrow physiologic range. Naturally occurring mutations in the calcium-sensing …

Genetic polymorphism (rs6776158) in CaSR gene is associated... : Medicine Genetic
polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in …