Natural killer (NK) cells play a crucial role in host immunity by detecting cells that
downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in …

Adoptive transfer of antitumor lymphocytes has gained intense interest in the field of cancer
therapeutics over the past two decades. Human natural killer (NK) cells are a promising …

Background aims Traditionally, natural killer (NK) cells are sourced from the peripheral
blood of donors―a laborious and highly donor-specific process. Processes for generating …

The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the
door to a new generation of regenerative medicine research. Among PSCs, the donors …

Current donor cell-dependent strategies can only produce limited" made-to-order"
therapeutic natural killer (NK) cells for limited patients. To provide unlimited" off-the-shelf" …

Cell therapy is emerging as a very promising therapeutic modality against cancer,
spearheaded by the clinical success of chimeric antigen receptor (CAR) modified T cells for …

Natural killer (NK) cells are key effectors of the innate immune system, protecting the host
from a variety of infections, as well as malignant cells. Recent advances in the field of NK …

Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of
immune surveillance. Given their ability to rapidly and effectively recognize and kill aberrant …

Human natural killer (NK) cell-based adoptive anticancer immunotherapy has gained
intense interest with many clinical trials actively recruiting patients to treat a variety of both …

Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …