Mitochondria have long been recognized as the generators of energy for the cell. Like any
other power source, however, mitochondria are highly vulnerable to inhibition or uncoupling …

Background: Cardiovascular diseases (CVDs) are one of the main factors responsible for
human morbidity and mortality. Since mitochondria play a critical role in the regulation of …

Metabolic syndromes (MS) are a cluster of disorders such as obesity, hypertension,
dyslipidemia, and diabetes. Cardiometabolic syndrome (CMS), a branch of MS, is a group of …

Mitochondrial dysfunction has been defined as a reduced efficiency of mitochondria to
produce ATP given by a loss of mitochondrial membrane potential, alterations in the electron …

Mitochondrial dysfunction is a fundamental mechanism in the pathogenesis of several
significant toxicities in mammals, especially those associated with the liver, skeletal and …

Present-day drug therapies provide clear beneficial effects as many diseases can be driven
into remission and the symptoms of others can be efficiently managed; however, the success …

Mitochondrial dysfunctions are recognized as major factors for various diseases including
cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases …

Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal
mitochondrial function impairs cellular energy and lipid metabolism and leads to the …

Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for
various physiological activities of the cell. Cardiomyocytes have a high density of …

Drug-induced mitochondrial toxicity is rapidly gaining recognition within the pharmaceutical
industry as a contributor to compound attrition and post-market drug withdrawals. This article …