[HTML][HTML] Comparative genomic analyses reveal core-genome-wide genes under positive selection and major regulatory hubs in outlier strains of Pseudomonas …

U Sood, P Hira, R Kumar, A Bajaj, DLN Rao… - Frontiers in …, 2019 - frontiersin.org
Genomic information for outlier strains of Pseudomonas aeruginosa is exiguous when
compared with classical strains. We sequenced and constructed the complete genome of an …

Single-Nucleotide Polymorphism-Based Genetic Diversity Analysis of Clinical Pseudomonas aeruginosa Isolates

U Muthukumarasamy, M Preusse… - Genome Biology and …, 2020 - academic.oup.com
Extensive use of next-generation sequencing has the potential to transform our knowledge
on how genomic variation within bacterial species impacts phenotypic versatility. Because …

Genomic complexity and plasticity ensure Pseudomonas success

KP Rumbaugh - FEMS Microbiology Letters, 2014 - academic.oup.com
The first Pseudomonas genome was sequenced in 2000, and at 6.3 million base pairs, it
was, at the time, the largest bacterial genome ever sequenced (Stover et al., 2000). Not …

Phylogroup-specific variation shapes the clustering of antimicrobial resistance genes and defence systems across regions of genome plasticity in Pseudomonas …

J Botelho, L Tüffers, J Fuss, F Buchholz, C Utpatel… - …, 2023 - thelancet.com
Background Pseudomonas aeruginosa is an opportunistic pathogen consisting of three
phylogroups (hereafter named A, B, and C). Here, we assessed phylogroup-specific …

Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa

A Dötsch, F Klawonn, M Jarek, M Scharfe, H Blöcker… - BMC genomics, 2010 - Springer
Background The constant increase in development and spread of bacterial resistance to
antibiotics poses a serious threat to human health. New sequencing technologies are now …

Pseudomonas aeruginosa Pangenome: Core and Accessory Genes of a Highly Resourceful Opportunistic Pathogen

KZ Abram, SR Jun, Z Udaondo - Pseudomonas aeruginosa: Biology …, 2022 - Springer
In this chapter, we leverage a novel approach to assess the seamless population structure of
Pseudomonas aeruginosa, using the full repertoire of genomes sequenced to date …

Insertion sequences drive the emergence of a highly adapted human pathogen

E Sentausa, P Basso, A Berry, A Adrait… - Microbial …, 2020 - microbiologyresearch.org
Pseudomonas aeruginosa is a highly adaptive opportunistic pathogen that can have serious
health consequences in patients with lung disorders. Taxonomic outliers of P. aeruginosa of …

Global Genotype-Phenotype Correlations in Pseudomonas aeruginosa

C Pommerenke, M Müsken, T Becker, A Dötsch… - PLoS …, 2010 - journals.plos.org
Once the genome sequence of an organism is obtained, attention turns from identifying
genes to understanding their function, their organization and control of metabolic pathways …

Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection

I Bianconi, J Jeukens, L Freschi, B Alcalá-Franco… - BMC genomics, 2015 - Springer
Background Pseudomonas aeruginosa establishes life-long chronic airway infections in
cystic fibrosis (CF) patients. As the disease progresses, P. aeruginosa pathoadaptive …

Draft genomes of 12 host-adapted and environmental isolates of Pseudomonas aeruginosa and their positions in the core genome phylogeny

L Stewart, A Ford, V Sangal, J Jeukens… - Pathogens and …, 2014 - academic.oup.com
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen particularly
associated with the inherited disease cystic fibrosis (CF). Pseudomonas aeruginosa is well …