RNA alternative splicing, a post-transcriptional stage in eukaryotes, is crucial in cellular
homeostasis and disease processes. Due to the rapid development of the next-generation …

The sequencing of the human genome and ensuing wave of data generation have brought
new light upon the extent and importance of alternative splicing as an RNA regulatory …

The alternative splicing code that controls and coordinates the transcriptome in complex
multicellular organisms remains poorly understood. It has long been argued that regulation …

Highlights•RNA-seq is emerging as a powerful technology to study alternative splicing.•RNA
mis-splicing can cause cancers and a variety of other human diseases.•To target alternative …

Alternative splicing is a key cellular mechanism for generating distinct isoforms, whose
relative abundances regulate critical cellular processes. It is therefore essential that …

Abstract RNA-sequencing (RNA-seq) can generate millions of reads to provide clues for
analyzing novel or abnormal alternative splicing (AS) events in cells. However, current …

Alternative splicing increases protein diversity by allowing multiple, sometimes functionally
distinct, proteins to be encoded by the same gene. It can be specific to tissues, stress …

An important step toward understanding gene regulation is the elucidation of the time
necessary for the completion of individual steps. Measurement of reaction rates can reveal …

Recent improvements in experimental and computational techniques that are used to study
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …

Alternative ribonucleic acid (RNA) splicing can lead to the assembly of different protein
isoforms with distinctive functions. The outcome of alternative splicing (AS) can result in a …