Background: Phenobarbital and midazolam are commonly used drugs in (near-) term
neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for …

Background: Midazolam is used as an anticonvulsant in neonatology, including newborns
with perinatal asphyxia treated with hypothermia. Hypothermia may affect the safety and …

Objective: Phenobarbital is the first-line treatment for neonatal seizures. Many neonates with
hypoxic ischemic encephalopathy are treated with therapeutic hypothermia, and about 40 …

Abstract Background and Objectives Therapeutic hypothermia can influence the
pharmacokinetics and pharmacodynamics of drugs, the discipline which is called …

Purpose: Therapeutic hypothermia has recently been introduced to treat term newborns with
hypoxic–ischemic encephalopathy, of whom more than half have seizures. Phenobarbital is …

Background Neonatal hypoxic ischaemic encephalopathy due to perinatal asphyxia, can
result in severe neurodevelopmental disability or mortality. Hypothermia is at present the …

Neonatal seizures constitute the most frequent presenting neurologic sign encountered in
the neonatal intensive care unit. Despite limited efficacy and safety data, phenobarbital …

Background Many drugs are used off-label or unlicensed in neonates. This does not mean
they are used without evidence or knowledge. We aimed to apply and evaluate the Grading …

Abstract Background In the Netherlands, perinatal asphyxia (severe perinatal oxygen
shortage) necessitating newborn resuscitation occurs in at least 200 of the 180–185.000 …

Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is
challenging; exposure is dependent on body size and maturation but can also be influenced …