Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Targeting inflammation as cancer therapy

M Wang, S Chen, X He, Y Yuan, X Wei - Journal of Hematology & …, 2024 - Springer
Inflammation has accompanied human beings since the emergence of wounds and
infections. In the past decades, numerous efforts have been undertaken to explore the …

Immunity, inflammation, and cancer: an eternal fight between good and evil

S Shalapour, M Karin - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Cancer development and its response to therapy are strongly influenced by innate and
adaptive immunity, which either promote or attenuate tumorigenesis and can have opposing …

[HTML][HTML] Immunity, inflammation, and cancer

SI Grivennikov, FR Greten, M Karin - Cell, 2010 - cell.com
Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation …

Inflammation and cancer: triggers, mechanisms, and consequences

FR Greten, SI Grivennikov - Immunity, 2019 - cell.com
Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …

Cancer-related inflammation: common themes and therapeutic opportunities

FR Balkwill, A Mantovani - Seminars in cancer biology, 2012 - Elsevier
Inflammatory cells and mediators are an essential component of the tumor
microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of …

The resolution of inflammation and cancer

J Rodriguez-Vita, T Lawrence - Cytokine & growth factor reviews, 2010 - Elsevier
Inflammation has long been thought to contribute to the development of cancer; however
there is also clear evidence that the immune system can recognize and eliminate cancer …

Analysis of the intricate relationship between chronic inflammation and cancer

EZP Chai, KS Siveen, MK Shanmugam… - Biochemical …, 2015 - portlandpress.com
Deregulated inflammatory response plays a pivotal role in the initiation, development and
progression of tumours. Potential molecular mechanism (s) that drive the establishment of …

Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?

J Hou, M Karin, B Sun - Nature reviews Clinical oncology, 2021 - nature.com
The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …

Cancer and inflammation

LL Munn - Wiley Interdisciplinary Reviews: Systems Biology …, 2017 - Wiley Online Library
The relationship between inflammation and cancer has been recognized since the 17th
century, 1 and we now know much about the cells, cytokines and physiological processes …