Abstract Background Sphingosine-1-phosphate (S1P), a key regulator of vascular
homeostasis and angiogenesis, is enriched in exosomes derived from platelet-rich plasma …

BACKGROUND: Blood platelets store sphingosine 1-phosphate (S1P) abundantly and
release this bioactive lipid extracellularly. S1P acts as an intercellular mediator through …

Wound healing starts with the recruitment of inflammatory cells that secrete wound-related
factors. This step is followed by fibroblast activation and tissue construction. Sphingosine-1 …

Impaired angiogenesis is one of the crucial factors that impede the wound healing process
in diabetic foot ulcers (DFUs). In this study, we found that 20 (S)-protopanaxadiol (PPD), an …

Nonhealing chronic wounds on foot induced by diabetes is a complicated pathologic
process. They are mainly caused by impaired neovascularization, neuropathy, and …

The hyperglycemia-induced production of oxidative stress results in endothelial cell
dysfunction. Previous studies have demonstrated that sphingosine-1-phosphate (S1P) …

Abstract Sphingosine-1-phosphate (S1P) is a pluripotent lipid mediator that transmits signals
through a family of G-protein-coupled receptors (GPCRs) to control diverse biological …

Objective Rheumatoid arthritis (RA) is a common inflammatory autoimmune disease
characterized by the formation of joint synovitis and pannus. Sphingosine 1-phosphate …

Endothelial dysfunction is believed the early stage of development of diabetic
cardiovascular complications. Sphingosine-1-phosphate (S1P) regulates various biological …

Abstract Background and Aims The traditional treatment of diabetic wounds is unsatisfactory.
Exosomes isolated from bone marrow mesenchymal stem cells (BMSCs) promote the …