Orofacial pain is a highly prevalent clinical condition, yet difficult to control effectively with
available drugs. Much attention is currently focused on the anti-inflammatory and …

Lectins are proteins of non-immunological origin that may play several biological
applications, of which we can highlight the anti-inflammatory and antinociceptive activities …

This study aimed to test for the possible antinociceptive effect of the naturally occurring
terpene citral in rodent models of acute and chronic orofacial pain and to test for the possible …

Coumarin and its derivatives are fragrant natural compounds isolated from the genus
Murraya that are flowering plants widely distributed in East Asia, Australia and the Pacific …

Background: The prevalence of long-term opiate use in treating chronic non-cancer pain is
increasing, and prescription opioid abuse and dependence are a major public health …

Capsaicin, an agonist of TRPV1, evokes intracellular [Ca 2+] transients and glutamate
release from perfused trigeminal ganglion. The spider toxin PnTx3-5, native or recombinant …

Formalin-evoked trigeminal pain behavior depends on TRPV4 calcium-permeable
channels, also on MEK-ERK signaling in trigeminal ganglion neurons. ABSTRACT …

Background: Essential oils are often used in alternative medicine as analgesic and anti-
inflammatory remedies. However, the specific compounds that confer the effects of essential …

Lectins are a heterogeneous group of proteins that reversibly bind to simple sugars or
complex carbohydrates. The plant lectin purified from the seed of Parkia platycephala (PPL) …

Background Transient receptor potential (TRP) cation channels are involved in the
perception of hot and cold pain and are targets for pain relief in humans. We hypothesized …