When stress becomes chronic it can trigger lasting brain and behavioral changes including
Major Depressive Disorder (MDD). There is conflicting evidence regarding whether …

There is high clinical interest in improving the pharmacological treatment of individuals with
Major Depressive Disorder (MDD). This neuropsychiatric disorder continues to cause …

Finding new antidepressant agents is of high clinical priority given that many cases of major
depressive disorder (MDD) do not respond to conventional monoaminergic antidepressants …

In today's society, numerous people suffer from anxiety and depression, so it is important to
develop effective treatments for these disorders. However, there is limited knowledge of the …

Symptoms of depression can be induced in humans through blockade of
acetylcholinesterase (AChE) whereas antidepressant-like effects can be produced in animal …

Background: A potent acetylcholinesterase inhibitor, donepezil is a cognitive enhancer
clinically used to treat neurodegenerative diseases. However, its complete pharmacological …

The cholinergic theory of depression highlights the involvement of muscarinic acetylcholine
receptors in the neurobiology of mood disorders. The present study was designed to …

Acetylcholine (ACh) levels are elevated in actively depressed subjects. Conversely,
antagonism of either nicotinic or muscarinic ACh receptors can have antidepressant effects …

Current literature suggests that nicotinic acetylcholine receptors (nAChRs) are involved in
major depression. In rodents, antidepressant-like effects of both nicotine and the non …

Rationale Alzheimer's dementia (AD) patients have profound deficits in cognitive and social
functions, mediated in part by a decline in cholinergic function. Acetylcholinesterase …