The development of autoimmune disease type 1 diabetes (T1D) is determined by both
genetic background and environmental factors. Environmental triggers include RNA viruses …

Diabetes is frequently associated with hypoxia and is known to impair ischaemia-induced
neovascularisation and other forms of adaptive cell and tissue responses to low oxygen …

Background Glucose increases the expression of glycolytic enzymes and other hypoxia-
response genes in pancreatic beta-cells. Here, we tested whether this effect results from the …

Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the
tissues. Hypoxia-inducible factors (HIFs) are critical regulators of the mammalian response …

Coxsackievirus B infections are suspected environmental triggers of type 1 diabetes (T1D)
and macrophage antiviral responses may provide a link to virus-induced T1D. We previously …

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that regulates cellular stress
responses. While the levels of HIF-1α protein are tightly regulated, recent studies suggest …

Type 1 diabetes acceleration in nonobese diabetic (NOD) mice through coxsackievirus B4
(CVB4) infection requires a preexisting critical mass of autoreactive T cells in pancreatic …

Hypoxia affects the function of pancreatic β cells, and the molecular mechanism underlying
hypoxia-related β cell dysfunction in human type 2 diabetes mellitus (T2DM) remains to be …

A detailed understanding of the molecular pathways and cellular interactions that result in
islet beta cell (β cell) destruction is essential for the development and implementation of …

During progression of type 2 diabetes, pancreatic β cells are subjected to sustained
metabolic overload. We postulated that this state mediates a hypoxic phenotype driven by …