Follicular CD8+ T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers
against lymphotropic infections and cancers, but the precise mechanisms by which these …

The functional properties of circulating CD8+ T cells have been associated with immune
control of HIV. However, viral replication occurs predominantly in secondary lymphoid …

Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies.
CD8+ T cells play a critical role in control of HIV, but their functional attributes in lymph …

Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells
and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 …

LN follicles constitute major reservoir sites for HIV/SIV persistence. Cure strategies could
benefit from the characterization of CD8+ T cells able to access and eliminate HIV-infected …

T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of
germinal center (GC) reactions, a critical process that promotes the generation of long-lived …

During chronic HIV infection, viral replication is concentrated in secondary lymphoid follicles.
Cytotoxic CD8 T cells control HIV replication in extrafollicular regions, but not in the follicle …

Human and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid
regions by establishing high levels of viral replication and dysregulating humoral immunity …

Current paradigms of CD8+ T cell–mediated protection in HIV infection center almost
exclusively on studies of peripheral blood, which is thought to provide a window into …

Virus-specific CD8+ T cells probably mediate control over HIV replication in rare individuals,
termed long-term nonprogressors (LTNPs) or elite controllers. Despite extensive …