Is viral E6 oncoprotein a viable target? A critical analysis in the context of cervical cancer
An understanding of the pathology of cervical cancer (CC) mediated by E6/E7 oncoproteins
of high‐risk human papillomavirus (HPV) was developed by late 80's. But if we look at the …
of high‐risk human papillomavirus (HPV) was developed by late 80's. But if we look at the …
Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment
Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical
cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant …
cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant …
Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins
AM Almeida, JA Queiroz, F Sousa, Â Sousa - Drug discovery today, 2019 - Elsevier
Highlights•Human papillomavirus (HPV) has a primordial role in the development of cervical
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …
Anticancer drugs aimed at E6 and E7 activity in HPV-positive cervical cancer
S Tan, E GE de Vries, A GJ van der Zee… - Current cancer drug …, 2012 - ingentaconnect.com
Standard treatment of locally advanced cervical cancer currently consists of concurrent
chemoradiation, leading to a 5-year disease-free survival of 66-79%, indicating that there is …
chemoradiation, leading to a 5-year disease-free survival of 66-79%, indicating that there is …
Cervical cancers require the continuous expression of the human papillomavirus type 16 E7 oncoprotein even in the presence of the viral E6 oncoprotein
SF Jabbar, S Park, J Schweizer, M Berard-Bergery… - Cancer research, 2012 - AACR
High-risk human papillomaviruses (HPV), such as HPV-16, are etiologic agents of a variety
of anogenital and oral malignancies, including nearly all cases of cervical cancer. Cervical …
of anogenital and oral malignancies, including nearly all cases of cervical cancer. Cervical …
Human papillomavirus E6 and E7: the cervical cancer hallmarks and targets for therapy
Human papillomavirus (HPV)-induced cervical cancer is a major health issue among
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …
Human papillomavirus: E6 and E7 oncogenes
G Boulet, C Horvath, DV Broeck, S Sahebali… - The international journal …, 2007 - Elsevier
The recognition of a causal relationship between human papillomaviruses and cancer
almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the …
almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the …
New HPV E6 binding proteins: dangerous liaisons?
MHG Kubbutat, KH Vousden - Trends in Microbiology, 1998 - cell.com
(HPVs) are by far the best characterized of the human tumor viruses and, as they contribute
to the development of almost all cervical cancers, represent a major disease worldwide. The …
to the development of almost all cervical cancers, represent a major disease worldwide. The …
Cellular binding partners of the human papillomavirus E6 protein
SS Tungteakkhun, PJ Duerksen-Hughes - Archives of virology, 2008 - Springer
The high-risk strains of human papillomavirus (HR-HPV) are known to be causative agents
of cervical cancer and have recently also been implicated in cancers of the oropharynx. E6 …
of cervical cancer and have recently also been implicated in cancers of the oropharynx. E6 …
Roles of E6 and E7 human papillomavirus proteins in molecular pathogenesis of cervical cancer
E Taghizadeh, S Jahangiri, D Rostami… - Current Protein and …, 2019 - ingentaconnect.com
Human papillomavirus (HPV) cancers are expected to be major global health concerns in
the upcoming decades. The growth of HPV-positive cancer cells depends on the consistent …
the upcoming decades. The growth of HPV-positive cancer cells depends on the consistent …