Is viral E6 oncoprotein a viable target? A critical analysis in the context of cervical cancer

A Kumar, E Rathi, RC Hariharapura… - Medicinal research …, 2020 - Wiley Online Library
An understanding of the pathology of cervical cancer (CC) mediated by E6/E7 oncoproteins
of high‐risk human papillomavirus (HPV) was developed by late 80's. But if we look at the …

Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment

MK Kim, HS Kim, SH Kim, JM Oh, JY Han… - Biochemical …, 2010 - Elsevier
Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical
cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant …

Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins

AM Almeida, JA Queiroz, F Sousa, Â Sousa - Drug discovery today, 2019 - Elsevier
Highlights•Human papillomavirus (HPV) has a primordial role in the development of cervical
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …

Anticancer drugs aimed at E6 and E7 activity in HPV-positive cervical cancer

S Tan, E GE de Vries, A GJ van der Zee… - Current cancer drug …, 2012 - ingentaconnect.com
Standard treatment of locally advanced cervical cancer currently consists of concurrent
chemoradiation, leading to a 5-year disease-free survival of 66-79%, indicating that there is …

Cervical cancers require the continuous expression of the human papillomavirus type 16 E7 oncoprotein even in the presence of the viral E6 oncoprotein

SF Jabbar, S Park, J Schweizer, M Berard-Bergery… - Cancer research, 2012 - AACR
High-risk human papillomaviruses (HPV), such as HPV-16, are etiologic agents of a variety
of anogenital and oral malignancies, including nearly all cases of cervical cancer. Cervical …

Human papillomavirus E6 and E7: the cervical cancer hallmarks and targets for therapy

A Pal, R Kundu - Frontiers in microbiology, 2020 - frontiersin.org
Human papillomavirus (HPV)-induced cervical cancer is a major health issue among
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …

Human papillomavirus: E6 and E7 oncogenes

G Boulet, C Horvath, DV Broeck, S Sahebali… - The international journal …, 2007 - Elsevier
The recognition of a causal relationship between human papillomaviruses and cancer
almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the …

New HPV E6 binding proteins: dangerous liaisons?

MHG Kubbutat, KH Vousden - Trends in Microbiology, 1998 - cell.com
(HPVs) are by far the best characterized of the human tumor viruses and, as they contribute
to the development of almost all cervical cancers, represent a major disease worldwide. The …

Cellular binding partners of the human papillomavirus E6 protein

SS Tungteakkhun, PJ Duerksen-Hughes - Archives of virology, 2008 - Springer
The high-risk strains of human papillomavirus (HR-HPV) are known to be causative agents
of cervical cancer and have recently also been implicated in cancers of the oropharynx. E6 …

Roles of E6 and E7 human papillomavirus proteins in molecular pathogenesis of cervical cancer

E Taghizadeh, S Jahangiri, D Rostami… - Current Protein and …, 2019 - ingentaconnect.com
Human papillomavirus (HPV) cancers are expected to be major global health concerns in
the upcoming decades. The growth of HPV-positive cancer cells depends on the consistent …