Background & Aims Telomerase activation is the earliest event in hepatocellular carcinoma
(HCC) development. Thus, we aimed to elucidate the role of telomere length maintenance …

Telomere maintenance and telomerase reactivation are near universal features of human
hepatocellular carcinoma (HCC), yet the shorter telomeres and highly abnormal cytogenetic …

Liver cancer is one of the most common cancer types worldwide and the fourth leading
cause of cancer-related death. Liver carcinoma is distinguished by a high heterogeneity in …

Telomerase is a key enzyme for cell survival that prevents telomere shortening and the
subsequent cellular senescence that is observed after many rounds of cell division. In …

Background & Aims: During early stages of carcinogenesis most human epithelial cancers
including hepatocellular carcinoma (HCC) have been observed to transit through a “crisis” …

Telomere shortening limits the proliferative capacity of primary human cells and restrains the
regenerative capacity of organ systems during chronic diseases and aging. Telomere …

Telomere shortening limits the proliferative capacity of a cell, but perhaps surprisingly,
shortening is also known to be associated with increased rates of tumor initiation. A current …

Telomerase reactivation and telomere maintenance are crucial in carcinogenesis and tumor
progression. In this study, the relationships between telomere parameters, chromosomal …

Telomeres protect chromosomal ends from deterioration and have been shown to be
susceptible to shortening by reactive oxygen species (ROS)‐induced damage. ROS levels …

Telomeres shorten progressively with age in normal somatic cells in culture and in vivo. The
maintenance of telomere length is assumed to be an obligatory step in the progression and …