[HTML][HTML] Prior cocaine exposure increases firing to immediate reward while attenuating cue and context signals related to reward value in the insula
The insula contributes to behavioral control and is disrupted by substance abuse, yet we
know little about the neural signals underlying these functions or how they are disrupted …
know little about the neural signals underlying these functions or how they are disrupted …
Insula lesions reduce stimulus-driven control of behavior during odor-guided decision-making and autoshaping
The insula has become a significant brain region in the study of both normal and impaired
behavior and decision-making and has emerged as an important contributor to drug …
behavior and decision-making and has emerged as an important contributor to drug …
A neuronal ensemble in the rostral agranular insula tracks cocaine-induced devaluation of natural reward and predicts cocaine seeking
TM Moschak, X Wang, RM Carelli - Journal of Neuroscience, 2018 - Soc Neuroscience
In substance use disorders, negative affect associated with drug withdrawal can elicit strong
drug craving and promote relapse. One brain region implicated in those processes is the …
drug craving and promote relapse. One brain region implicated in those processes is the …
Bidirectional regulation over the development and expression of loss of control over cocaine intake by the anterior insula
Rationale Increasing evidence suggests that the anterior insular cortex (AIC) plays a major
role in cocaine addiction, being implicated in both impaired insight and associated decision …
role in cocaine addiction, being implicated in both impaired insight and associated decision …
Previous cocaine self-administration disrupts reward expectancy encoding in ventral striatum
The nucleus accumbens core (NAc) is important for integrating and providing information to
downstream areas about the timing and value of anticipated reward. Although NAc is one of …
downstream areas about the timing and value of anticipated reward. Although NAc is one of …
Revisiting the role of the insula in addiction
Brain lesions that damage the insular cortex (IC) interrupt addictive behaviors, suggesting
that drug addiction sensitizes the insula. However, neuroimaging studies seem to lead to an …
that drug addiction sensitizes the insula. However, neuroimaging studies seem to lead to an …
Morphine reward promotes cue-sensitive learning: implication of dorsal striatal CREB activity
M Baudonnat, JL Guillou, M Husson, VD Bohbot… - Frontiers in …, 2017 - frontiersin.org
Different parallel neural circuits interact and may even compete to process and store
information: whereas stimulus–response (S–R) learning critically depends on the dorsal …
information: whereas stimulus–response (S–R) learning critically depends on the dorsal …
The Insula: A Critical Neural Substrate for Drug Seeking under Conflict and Risk
This chapter begins with a summary of the initial findings on the effects of insula lesions on
smoking behavior as well as more recent human‐lesion studies that replicate and extend …
smoking behavior as well as more recent human‐lesion studies that replicate and extend …
Prior cocaine self-administration increases response–outcome encoding that is divorced from actions selected in dorsal lateral striatum
AC Burton, GB Bissonette, AC Zhao… - Journal of …, 2017 - Soc Neuroscience
Dorsal lateral striatum (DLS) is a highly associative structure that encodes relationships
among environmental stimuli, behavioral responses, and predicted outcomes. DLS is known …
among environmental stimuli, behavioral responses, and predicted outcomes. DLS is known …
The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making
We have recently shown that damage to the insula leads to a profound disruption of
addiction to cigarette smoking (Naqvi et al., Science 315: 531–534, 2007). Yet, there is little …
addiction to cigarette smoking (Naqvi et al., Science 315: 531–534, 2007). Yet, there is little …