The Effects of Stressful Life Events on Epigenetic Modification: An Association Between the FKBP5 gene and the Onset of Mental Disorders
G Zachariadis - 2019 - studenttheses.uu.nl
This dissertation consists of two parts. This first part serves as a literature review integrating
studies measuring DNA methylation in a variety of genes following recent and/or chronic life …
studies measuring DNA methylation in a variety of genes following recent and/or chronic life …
Dissecting the molecular mechanisms of gene x environment interactions: implications for diagnosis and treatment of stress-related psychiatric disorders
EB Binder - European journal of psychotraumatology, 2017 - Taylor & Francis
Epidemiological studies indicate a combined contribution of genetic and environmental
factors, mainly exposure to adverse life events, in the risk for psychiatric disease …
factors, mainly exposure to adverse life events, in the risk for psychiatric disease …
Allele-specific epigenetic modification: a molecular mechanism for gene–environment interactions in stress-related psychiatric disorders?
As for most common disorders, the pathogenic forces underlying psychiatric disorders are
complex, with both environmental and genetic factors contributing to risk [1]. For a series of …
complex, with both environmental and genetic factors contributing to risk [1]. For a series of …
[PDF][PDF] Epigenetic mechanisms of fine-tuning FKBP5 gene expression
T Wiechmann - 2019 - pure.mpg.de
The development of stress-related psychiatric disorders involves the integration of genetic
and environmental factors. How these factors are integrated on a molecular level to …
and environmental factors. How these factors are integrated on a molecular level to …
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …
development and function of the human brain and, ultimately, the risk of psychiatric …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
[引用][C] Evidence Mounting for Gene-by-Environment Interactions at the FKBP5 Locus Predicting Psychiatric Symptoms
T Halldorsdottir - Biological Psychiatry, 2016 - biologicalpsychiatryjournal.com
Gene variants moderating the stress response and the regulation of the hypothalamic-
pituitary-adrenal axis have proven to be among the most promising candidates for gene …
pituitary-adrenal axis have proven to be among the most promising candidates for gene …
Epigenetic signature of childhood trauma
T Klengel - 2016 - edoc.ub.uni-muenchen.de
Childhood abuse is one of the major risk factors for the development of adult
psychopathology though the response to childhood abuse and other types of early life …
psychopathology though the response to childhood abuse and other types of early life …
[引用][C] F216. Genotype and Early Life Stress Interaction on FKBP5 Methylation in Schizophrenia
J Chiappelli, R Lee, O Cox… - Biological …, 2018 - biologicalpsychiatryjournal.com
Background Epigenetic modulation of genes involved in regulating the hypothalamic-
pituitary-adrenal (HPA) axis has been hypothesized to be a mechanism explaining the …
pituitary-adrenal (HPA) axis has been hypothesized to be a mechanism explaining the …
FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls
N Höhne, M Poidinger, F Merz, H Pfister… - International Journal …, 2015 - academic.oup.com
Background: Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been
shown to influence glucocorticoid receptor sensitivity, stress response regulation, and …
shown to influence glucocorticoid receptor sensitivity, stress response regulation, and …