Transgenic mice are used to model increased brain amyloid-β (Aβ) and amyloid plaque
formation reflecting Alzheimer's disease pathology. In our study hippocampal network …

Alzheimer's disease (AD) is pathologically characterized by amyloid-β (Aβ) accumulation,
which induces Aβ-dependent neuronal dysfunctions. We focused on the early-stage disease …

Current findings suggest that accumulation of amyloid-β (Aβ) and hyperphosphorylated tau
in the brain disrupt synaptic function in hippocampal–cortical neuronal networks leading to …

Background Alzheimer disease (AD) is a neurodegenerative disorder for which there is no
cure. We have investigated synaptic plasticity in area CA1 in a novel AD mouse model …

Alzheimer's disease (AD) is an age‐related neurodegenerative disorder characterized by
memory impairments. Brain oscillatory activity is critical for cognitive function and is altered …

In the last decade, multiple lines of transgenic APP overexpressing mice have been created
that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the …

APP. V717I and Tau. P301L transgenic mice develop Alzheimer's disease pathology
comprising important aspects of human disease including increased levels of amyloid …

Alzheimer's disease (AD) is characterized by progressive memory impairment and the
formation of amyloid plaques in the brain. Dysfunctional excitatory synaptic transmission and …

Genetically modified mice have provided insights into the progression and pathology of
Alzheimer's disease (AD). Here, we have examined two mouse models of AD: the rTg4510 …

Amyloid precursor protein (APP) is critically involved in the pathophysiology of Alzheimer's
disease, but its physiological functions remain elusive. Importantly, APP knockout (APP-KO) …