Eliciting α7‐nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling

ZH Lin, YC Li, SJ Wu, C Zheng, YZ Lin… - Journal of Cellular …, 2019 - Wiley Online Library
Our previous studies have reported that agonist of α7 nicotinic acetylcholine receptors
prevented electrophysiological dysfunction of rats with ischaemic cardiomyopathy (ICM) by …

Activating α7nAChR helps post-myocardial infarction healing by regulating macrophage polarization via the STAT3 signaling pathway

XH Niu, RH Liu, X Lv, RL He, FZ Lv, SJ Wu, XQ Li… - Inflammation …, 2023 - Springer
Background Monocytes/macrophages play critical roles in inflammation and cardiac
remodeling following myocardial infarction (MI). The cholinergic anti-inflammatory pathway …

α7nAChR Deletion Aggravates Myocardial Infarction and Enhances Systemic Inflammatory Reaction via mTOR-Signaling-Related Autophagy

J Fang, J Wang, F Chen, Y Xu, H Zhang, Y Wang - Inflammation, 2019 - Springer
Alpha7 nicotinic acetylcholine receptor (α7nAChR) has been previously reported to play an
alleviative role in myocardial infarction (MI). In this study, we investigated its specific …

Protective Effect of PNU-120596, a Selective Alpha7 Nicotinic Acetylcholine Receptor–positive Allosteric Modulator, on Myocardial Ischemia–reperfusion Injury in Rats

H Li, ZZ Zhang, J Zhan, XH He, XM Song… - Journal of …, 2012 - journals.lww.com
The cholinergic anti-inflammatory pathway has been found to exert a protective role in
myocardial ischemia–reperfusion injury (MIRI). Alpha7 nicotinic acetylcholine receptor …

[HTML][HTML] Alpha 7 Nicotinic Acetylcholine Receptor Agonist PHA 568487 Reduces Acute Inflammation but Does Not Affect Cardiac Function or Myocardial Infarct Size in …

F Mjörnstedt, A Miljanovic, R Wilhelmsson… - International Journal of …, 2024 - mdpi.com
Stimulation of the alpha 7 nicotinic acetylcholine receptor (α7nAChR) has shown beneficial
effects in several acute inflammatory disease models. This study aims to examine whether …

[HTML][HTML] Protective role of the cholinergic anti-inflammatory pathway in a mouse model of viral myocarditis

Z Cheng, G Li-Sha, Z Jing-Lin, Z Wen-Wu, C Xue-Si… - PLoS …, 2014 - journals.plos.org
Background Activation of the cholinergic anti-inflammatory pathway, which relies on the
α7nAchR (alpha 7 nicotinic acetylcholine receptor), has been shown to decrease …

Alpha7 nicotinic acetylcholine receptor activation protects against myocardial reperfusion injury through modulation of autophagy

Z Hou, Y Zhou, H Yang, Y Liu, X Mao, X Qin, X Li… - Biochemical and …, 2018 - Elsevier
Alpha7 nicotinic acetylcholine receptor (α7nAChR) activation alleviates myocardial
ischemia/reperfusion (MI/R) injury. However, the underlying mechanisms remain unclear …

[HTML][HTML] N-propargyl caffeamide skews macrophages towards a resolving M2-like phenotype against myocardial ischemic injury via activating Nrf2/HO-1 pathway and …

Y Cheng, C Yang, D Luo, X Li, XC Le… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Macrophages exhibit dynamic pro-inflammatory and resolving activities in
myocardial infarction. The present study investigated whether caffeic acid derivatives could …

Role of the cholinergic antiinflammatory pathway in murine autoimmune myocarditis

C Leib, S Göser, D Lüthje, R Öttl, T Tretter… - Circulation …, 2011 - Am Heart Assoc
Rationale: This study was performed to gain insights into novel therapeutic approaches for
the treatment of autoimmune myocarditis. Objective: Chemical stimulation of the efferent arm …

Targeting CaMKII-δ9 ameliorates cardiac ischemia/reperfusion injury by inhibiting myocardial inflammation

Y Yao, F Li, M Zhang, L Jin, P Xie, D Liu… - Circulation …, 2022 - Am Heart Assoc
Background: CaMKII (Ca2+/calmodulin-dependent kinase II) plays a central role in cardiac
ischemia/reperfusion (I/R) injury—an important therapeutic target for ischemic heart disease …