The Role of Abnormal Placentation in Congenital Heart Defects

JA Courtney - 2021 - search.proquest.com
Congenital heart disease (CHD) is the most common birth defect, and unexplained CHD
may be secondary to undiscovered roles of gene/environment interactions. Improper …

Conditional mutation of Hand1 in the mouse placenta disrupts placental vascular development resulting in fetal loss in both early and late pregnancy

JA Courtney, RL Wilson, J Cnota, HN Jones - International Journal of …, 2021 - mdpi.com
Congenital heart defects (CHD) affect approximately 1% of all live births, and often require
complex surgeries at birth. We have previously demonstrated abnormal placental …

Prenatal congenital heart disease and placental phenotypes: preserved neonatal weight despite small placentas

A Desmond, H Imany-Shakibai, D Wong, L Kwan… - JACC: Advances, 2023 - jacc.org
Background Congenital heart disease (CHD) affects 8 in 1,000 live births with significant
postnatal implications including growth failure, neurodevelopmental delay, and mortality …

Placenta crucially affects formation of fetal congenital heart disease

VI Tsibizova, TM Pervunina, VA Artemenko… - Obstetrics, Gynecology …, 2022 - gynecology.su
It has been increasingly recognized that structural abnormalities and functional changes in
the placenta can adversely affect developing fetal heart. In this article, we examine a role of …

Evidence for uteroplacental malperfusion in fetuses with major congenital heart defects

J Binder, S Carta, JS Carvalho, E Kalafat, A Khalil… - PloS one, 2020 - journals.plos.org
Aims Fetuses affected by congenital heart defects (CHD) are considered to be at increased
risk of fetal growth restriction and intrauterine demise. Whether these risks are a direct …

The role of abnormal placentation in congenital heart disease; cause, correlate, or consequence?

JA Courtney, JF Cnota, HN Jones - Frontiers in Physiology, 2018 - frontiersin.org
Congenital heart disease (CHD) is the most common birth defect, affecting~ 1% of all live
births (van der Linde et al.,). Despite improvements in clinical care, it is the leading cause of …

[HTML][HTML] Placental abnormalities in congenital heart disease

NN Andescavage, C Limperopoulos - Translational pediatrics, 2021 - ncbi.nlm.nih.gov
Congenital heart disease (CHD) remains the most common birth defect in infants, and
critical CHD is associated with significant rates of morbidity and mortality. With the advent of …

Abnormalities of placental development and function are associated with the different fetal growth patterns of hypoplastic left heart syndrome and transposition of the …

J Courtney, W Troja, KJ Owens, HM Brockway… - Placenta, 2020 - Elsevier
Background Birthweight is a critical predictor of congenital heart disease (CHD) surgical
outcomes. Hypoplastic left heart syndrome (HLHS) is cyanotic CHD with known fetal growth …

Interdependence of placenta and fetal cardiac development

RL Leon, L Bitar, V Rajagopalan… - Prenatal Diagnosis, 2024 - Wiley Online Library
The placenta and fetal heart undergo development concurrently during early pregnancy,
and, while human studies have reported associations between placental abnormalities and …

Shared developmental pathways of the placenta and fetal heart

A Mahadevan, A Tipler, H Jones - Placenta, 2023 - Elsevier
Congenital heart defects (CHD) remain the most common class of birth defect worldwide,
affecting 1 in every 110 live births. A host of clinical and morphological indicators of …