The unrivalled power of lipids to form macromolecular lipid assemblies and the shear three-
dimensional plasticity of these assemblies have suggested a number of very important …

Lipids and nucleic acids (NAs) can hierarchically self-organize into a variety of
nanostructures of increasingly complex geometries such as the 1D lamellar, 2D hexagonal …

The investigation of the self‐assembly between nucleic acids and cationic molecules, such
as lipids, polymers, or dendrimers, has guided and will continue to guide the development of …

Gene delivery into cultured cells or in vivo is a promising approach to the treatment of
diseases. Several gene delivery systems have been developed to promote gene expression …

Recently, there has been a flurry of experimental work on understanding the supramolecular
assemblies that are formed when cationic liposomes (CLs) are mixed with DNA. From a …

Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …

Protein expression and RNA interference require efficient delivery of DNA or mRNA and
small double stranded RNA into cells, respectively. Although cationic lipids are the most …

A viewpoint now emerging is that a critical factor in lipid-mediated transfection (lipofection) is
the structural evolution of lipoplexes upon interaction with anionic cellular lipids, resulting in …

Twenty years after gene therapy was introduced in the clinic, advances in the technique
continue to garner headlines as successes pique the interest of clinicians, researchers, and …

Gene therapy and gene silencing techniques are based on the insertion of nucleic acids
(DNA or siRNA) into cells, with the goal of inducing therapeutic changes in cell functions …