[HTML][HTML] Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies

SG Pereira, J Moura, E Carvalho… - Frontiers in …, 2017 - frontiersin.org
World Health Organization considered diabetes as one of the 20th century epidemics,
estimating that over 10% of the world population is diabetic or at high risk. Self-assessment …

Strain-and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy

LR Kalan, JS Meisel, MA Loesche, J Horwinski… - Cell host & …, 2019 - cell.com
Chronic wounds are a major complication of diabetes associated with high morbidity and
health care expenditures. To investigate the role of colonizing microbiota in diabetic wound …

New molecular techniques to study the skin microbiota of diabetic foot ulcers

JP Lavigne, A Sotto, C Dunyach-Remy… - Advances in wound …, 2015 - liebertpub.com
Significance: Diabetic foot ulcers (DFU) are a major and growing public health problem.
They pose difficulties in clinical practice in both diagnosis and management. Bacterial …

Colonizing microbiota is associated with clinical outcomes in diabetic wound healing

G Wang, Z Lin, Y Li, L Chen, SK Reddy, Z Hu… - Advanced drug delivery …, 2023 - Elsevier
With the development of society and the improvement of life quality, more than 500 million
people are affected by diabetes. More than 10% of people with diabetes will suffer from …

The role of the microbiome in nonhealing diabetic wounds

LR Kalan, MB Brennan - Annals of the New York Academy of …, 2019 - Wiley Online Library
Wound healing is a highly coordinated and complex process, and there can be devastating
consequences if it is interrupted. It is believed that, in combination with host factors …

The gut-skin microbiota axis and its role in diabetic wound healing—a review based on current literature

BK Patel, KH Patel, RY Huang, CN Lee… - International journal of …, 2022 - mdpi.com
Diabetic foot ulcers (DFU) are a growing concern worldwide as they pose complications in
routine clinical practices such as diagnosis and management. Bacterial interactions on the …

Wound chronicity, impaired immunity and infection in diabetic patients

N Rodríguez-Rodríguez, I Martínez-Jiménez… - MEDICC …, 2022 - SciELO Public Health
BACKGROUND Diabetic foot ulcers are a common diabetic complication leading to
alarming figures of amputation, disability, and early mortality. The diabetic glucooxidative …

Microbial community distribution and core microbiome in successive wound grades of individuals with diabetic foot ulcers

A Jnana, V Muthuraman, VK Varghese… - Applied and …, 2020 - Am Soc Microbiol
Diabetic foot ulcer (DFU) is a major complication of diabetes with high morbidity and
mortality rates. The pathogenesis of DFUs is governed by a complex milieu of environmental …

High levels of oxidative stress create a microenvironment that significantly decreases the diversity of the microbiota in diabetic chronic wounds and promotes biofilm …

JH Kim, PR Ruegger, EG Lebig… - Frontiers in Cellular …, 2020 - frontiersin.org
Diabetics chronic wounds are characterized by high levels of oxidative stress (OS) and are
often colonized by biofilm-forming bacteria that severely compromise healing and can result …

The dynamic wound microbiome

C Liu, AJ Ponsero, DG Armstrong, BA Lipsky… - BMC medicine, 2020 - Springer
Abstract Background Diabetic foot ulcers (DFUs) account for the majority of all limb
amputations and hospitalizations due to diabetes complications. With 30 million cases of …