Host-pathogen interactions of clinical S. aureus isolates to induce infective endocarditis

C Schwarz, Y Töre, V Hoesker, S Ameling, K Grün… - Virulence, 2021 - Taylor & Francis
To evaluate potential pathomechanisms in the induction of infective endocarditis (IE), 34
Staphylococcus aureus (S. aureus) isolates, collected from patients with S. aureus …

S. aureus endocarditis: clinical aspects and experimental approaches

V Hoerr, M Franz, MW Pletz, M Diab, S Niemann… - International Journal of …, 2018 - Elsevier
Infective endocarditis (IE) is a life-threatening disease, caused by septic vegetations and
inflammatory foci on the surface of the endothelium and the valves. Due to its complex and …

[HTML][HTML] Host–Bacterium Interaction Mechanisms in Staphylococcus aureus Endocarditis: A Systematic Review

F Nappi, SS Avtaar Singh - International Journal of Molecular Sciences, 2023 - mdpi.com
Staphylococci sp. are the most commonly associated pathogens in infective endocarditis,
especially within high-income nations. This along with the increasing burden of healthcare …

Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves

L Liesenborghs, S Meyers, M Lox, M Criel… - European heart …, 2019 - academic.oup.com
Aims The pathogenesis of endocarditis is not well understood resulting in unsuccessful
attempts at prevention. Clinical observations suggest that Staphylococcus aureus infects …

In vitro endothelial cell damage is positively correlated with enhanced virulence and poor vancomycin responsiveness in experimental endocarditis due to methicillin …

K Seidl, AS Bayer, JA McKinnell, S Ellison… - Cellular …, 2011 - Wiley Online Library
The pathogenesis of Staphylococcus aureus infective endocarditis (IE) is postulated to
involve invasion and damage of endothelial cells (ECs). However, the precise relationships …

[HTML][HTML] Isolating crucial steps in induction of infective endocarditis with preclinical modeling of host pathogen interaction

C Schwarz, V Hoerr, Y Töre, V Hösker… - Frontiers in …, 2020 - frontiersin.org
Animal models of Staphylococcus aureus infective endocarditis (IE), especially in rodents,
are commonly used to investigate the underlying pathogenesis, disease progression …

Use of a human-like low-grade bacteremia model of experimental endocarditis to study the role of Staphylococcus aureus adhesins and platelet aggregation in early …

TR Veloso, A Chaouch, T Roger, M Giddey… - Infection and …, 2013 - Am Soc Microbiol
Animal models of infective endocarditis (IE) induced by high-grade bacteremia revealed the
pathogenic roles of Staphylococcus aureus surface adhesins and platelet aggregation in the …

[HTML][HTML] All Staphylococcus aureus bacteraemia-inducing strains can cause infective endocarditis: Results of GWAS and experimental animal studies

S Bastien, S Meyers, W Salgado-Pabón, SG Giulieri… - Journal of Infection, 2023 - Elsevier
Objectives We aimed at determining whether specific S. aureus strains cause infective
endocarditis (IE) in the course of Staphylococcus aureus bacteraemia (SAB). Methods A …

Virulence factors of Staphylococcus aureus strains causing infective endocarditis – a comparison with strains from skin infections

H Hogevik, B Söderquist, HS TUNG, L Olaison… - Apmis, 1998 - Wiley Online Library
The objective was to study potential bacterial virulence factors in S. aureus endocarditis. S.
aureus strains isolated from patients with well‐classified episodes of infective endocarditis …

Relationship between pathogenic, clinical, and virulence factors of Staphylococcus aureus in infective endocarditis versus uncomplicated bacteremia: a case–control …

MM Gallardo-Garcia, G Sánchez-Espín… - European Journal of …, 2016 - Springer
Pathogenic factors of Staphylococcus aureus (SA) in the development of infective
endocarditis (IE) have not been sufficiently investigated. The purpose of this study was to …