Objectives Accumulating evidence reveals the association between the risk of never-smoker
lung cancer and family history of cancer. However, the clinicogenomic effect of family history …

Familial risk of lung cancer has been widely studied but whether this association holds in
non-smoking females is largely unknown. We sought to determine the relationship between …

The purpose of this study is to investigate the impact of positive cancer/lung cancer family
history (FH) on clinical features and outcome in non-small cell lung cancer (NSCLC) …

The aim of this study was to determine the distribution of known oncogenic driver mutations
in female never-smoker Asian patients with lung adenocarcinoma. We analyzed 214 …

Background Although smoking is a primary cause of lung cancer, females are
overrepresented among never-smokers with the disease. The mutational landscape of …

Objective Some population-based studies involving lung cancer patients have reported that
inherited susceptibility is responsible for the familial aggregation observed in non-smoking …

Purpose Lung cancer is strongly associated to tobacco smoking. However, global statistics
estimate that in females the proportion of lung cancer cases that is unrelated to tobacco …

INTRODUCTION: Inherited susceptibility to lung cancer is understudied. Never smokers are
an important subgroup of patients enriched for tumors harboring oncogene aberrations in …

PURPOSE Approximately 10%-40% of patients with lung cancer report no history of tobacco
smoking (never-smokers). We analyzed whole-exome and RNA-sequencing data of 160 …

Never-smoker lung adenocarcinoma (NSLA) is prevalent in Asian populations, particularly
in women. EGFR mutations and anaplastic lymphoma kinase (ALK) fusions are major …