24P Preliminary data on INHERITY LC: Germline mutations of a cohort of selected non-small cell lung cancer (NSCLC) patients

M Zurera, R Lastra, L Mezquita, OH Gomez… - Annals of …, 2022 - annalsofoncology.org
Background Almost 15% of NSCLCs are not attributable to smoking risk factor and genetic
predisposition to this disease has not been broadly studied, especially in non-Asian …

Driver mutations determine survival in smokers and never‐smokers with stage IIIB/IV lung adenocarcinomas

PK Paik, ML Johnson, SP D'Angelo, CS Sima, D Ang… - Cancer, 2012 - Wiley Online Library
BACKGROUND: The authors previously demonstrated that never‐smokers with stage IIIB/IV
nonsmall cell lung cancer (NSCLC) lived 50% longer than former/current smokers. This …

Germline mutations and age at onset of lung adenocarcinoma

KL Reckamp, CE Behrendt, TP Slavin, SW Gray… - Cancer, 2021 - Wiley Online Library
Background To identify additional at‐risk groups for lung cancer screening, which targets
persons with a long history of smoking and thereby misses younger or nonsmoking cases …

[HTML][HTML] Non-small cell lung cancer genomics around the globe: focus on ethnicity

LH Araujo, DP Carbone - Journal of Thoracic Disease, 2017 - ncbi.nlm.nih.gov
© Journal of Thoracic Disease. All rights reserved. J Thorac Dis 2017; 9 (4): E392-E394 jtd.
amegroups. com driver mutation rate was somewhat lower, suggesting that other, non …

Abstract SY26-02: Sherlock-Lung: Tracing lung cancer mutational processes in never smokers

MT Landi, T Zhang, M Garcia-Closas, Y Bossé, J Shi… - Cancer Research, 2019 - AACR
Globally, about 2 million people are diagnosed with lung cancer annually, making it the most
common type of cancer in the world. In addition, lung cancer is the leading cause of cancer …

Inactivating mutations and hypermethylation of the NKX2‐1/TTF‐1 gene in non‐terminal respiratory unit‐type lung adenocarcinomas

D Matsubara, M Soda, T Yoshimoto, Y Amano… - Cancer …, 2017 - Wiley Online Library
The major driver mutations of lung cancer, EGFR mutations and EML 4‐ALK fusion, are
mainly detected in terminal respiratory unit (TRU)‐type lung adenocarcinomas, which …

Family history and lung cancer risk: international multicentre case–control study in Eastern and Central Europe and meta-analyses

J Lissowska, L Foretova, J Dąbek, D Zaridze… - Cancer causes & …, 2010 - Springer
Lung cancer is the most common neoplastic disease in Eastern and Central Europe. The
role of hereditary factors in lung carcinogenesis is not fully understood. Family history (FH) of …

[HTML][HTML] Lung cancer risk in never-smokers of European descent is associated with genetic variation in the 5p15. 33 TERT-CLPTM1Ll region

RJ Hung, MR Spitz, RS Houlston, AG Schwartz… - Journal of Thoracic …, 2019 - Elsevier
Introduction Inherited susceptibility to lung cancer risk in never-smokers is poorly
understood. The major reason for this gap in knowledge is that this disease is relatively …

Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies

MJ Thun, LM Hannan, LL Adams-Campbell… - PLoS …, 2008 - journals.plos.org
Background Better information on lung cancer occurrence in lifelong nonsmokers is needed
to understand gender and racial disparities and to examine how factors other than active …

Analysis of driver mutations in female non-smoker Asian patients with pulmonary adenocarcinoma

S Ren, P Kuang, L Zheng, C Su, J Li, B Li… - Cell biochemistry and …, 2012 - Springer
Previous studies have revealed that EGFR mutation and/or EML4–ALK gene fusion rate was
higher in the non-smoker Asian females with pulmonary adenocarcinoma. The aim of this …