Redox proteomics and amyloid β‐peptide: insights into Alzheimer disease

DA Butterfield, D Boyd‐Kimball - Journal of neurochemistry, 2019 - Wiley Online Library
Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with aging
and characterized pathologically by the presence of senile plaques, neurofibrillary tangles …

Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

DA Butterfield, T Reed, SF Newman… - Free Radical Biology and …, 2007 - Elsevier
Oxidative stress has been implicated to play a crucial role in the pathogenesis of a number
of diseases, including neurodegenerative disorders, cancer, and ischemia, just to name a …

Redox proteomics identification of oxidatively modified proteins in Alzheimer's disease brain and in vivo and in vitro models of AD centered around Aβ (1–42)

R Sultana, M Perluigi, DA Butterfield - Journal of Chromatography B, 2006 - Elsevier
Alzheimer's disease is a progressive neurodegenerative disease associated with loss of
memory and cognition. One hallmark of AD is the accumulation of amyloid β-peptide (Aβ) …

Oxidative modification of brain proteins in Alzheimer's disease: perspective on future studies based on results of redox proteomics studies

R Sultana, DA Butterfield - Journal of Alzheimer's Disease, 2013 - content.iospress.com
Aging is the major risk factor associated with neurodegenerative diseases, including
Alzheimer's disease (AD). Until now no clear understanding of the mechanisms of initiation …

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

DA Butterfield, AM Swomley… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …

Oxidative stress, amyloid-β peptide, and altered key molecular pathways in the pathogenesis and progression of Alzheimer's disease

DA Butterfield, D Boyd-Kimball - Journal of Alzheimer's …, 2018 - content.iospress.com
Oxidative stress is implicated in the pathogenesis and progression of Alzheimer's disease
(AD) and its earlier stage, amnestic mild cognitive impairment (aMCI). One source of …

Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this …

DA Butterfield, R Sultana - Journal of Alzheimer's Disease, 2007 - content.iospress.com
Alzheimer disease is a common age-related neurodegenerative disease characterized
pathologically by senile plaques, neurofibrillary tangles, synaptic disruption, and …

Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

R Sultana, M Perluigi, DA Butterfield - Acta neuropathologica, 2009 - Springer
Oxidative stress has been implicated in the pathogenesis of a number of diseases including
Alzheimer's disease (AD). The oxidative stress hypothesis of AD pathogenesis, in part, is …

[HTML][HTML] Abeta, oxidative stress in Alzheimer disease: evidence based on proteomics studies

AM Swomley, S Förster, JT Keeney, J Triplett… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The initiation and progression of Alzheimer disease (AD) is a complex process not yet fully
understood. While many hypotheses have been provided as to the cause of the disease, the …

Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain

DA Butterfield - Brain research, 2004 - Elsevier
In Alzheimer's disease (AD) brain oxidative stress is observed indexed by several markers,
among which are protein carbonyls and 3-nitrotyrosine, markers for protein oxidation. We …