Patients with tension-type headache (TTH) have an increased risk of developing arterial
hypertension (AH), while hypertensive subjects do seem to have an increased risk of TTH …

Background: Nitric oxide (NO) is an important autocrine and paracrine signaling molecule
that plays a crucial role in cardiovascular physiology and pathology regulation. NO is an …

Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a
number of studies confirming and explaining their comorbidity. We searched PubMed …

Chronic pain syndromes are an important medical problem generated by various molecular,
genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic …

Nitric oxide (NO) is thought to reduce blood pressure by evoking vasodilation either directly
by causing relaxation of vascular smooth muscle or indirectly by acting in the rostral …

Background/Objectives Many biochemical, pharmacological, neuropathological, and
experimental data suggest a possible role of nitric oxide in the pathogenesis of migraine. We …

Nitric oxide synthase 3 (NOS3) catalyzes production of NO in the endothelium and may play
a role in cardiovascular disease (CVD). We assessed the pharmacogenetic associations of …

The pathogenic mechanisms involved in migraine are complex and not completely clarified.
Because there is evidence for the involvement of nitric oxide (NO) in migraine …

Publisher Summary This chapter focuses on recent advances in the design of the selective
inhibitors of nitric oxide synthase (NOS) and some of the emerging preclinical and clinical …

Because nitric oxide could play an important role in the pathogenesis of migraine
(suggested by experimental, neuropathological, biochemical, and pharmacological data) …