Epigenetic effects of paternal cocaine on reward stimulus behavior and accumbens gene expression in mice
Paternal cocaine use causes phenotypic alterations in offspring behavior and associated
neural processing. In rodents, changes in first generation (F1) offspring include drug reward …
neural processing. In rodents, changes in first generation (F1) offspring include drug reward …
Altered reward sensitivity in female offspring of cocaine-exposed fathers
DK Fischer, RC Rice, AM Rivera, M Donohoe… - Behavioural brain …, 2017 - Elsevier
Recent rodent studies have demonstrated that parental cocaine exposure can influence
offspring behavior, supporting the idea that environmental insults can impact subsequent …
offspring behavior, supporting the idea that environmental insults can impact subsequent …
Subtle biobehavioral effects produced by paternal cocaine exposure
CE Killinger, S Robinson, GD Stanwood - Synapse, 2012 - Wiley Online Library
Despite the increased prevalence of cocaine use and abuse in males when compared with
females, possible effects of paternal cocaine exposure on biobehavioral development have …
females, possible effects of paternal cocaine exposure on biobehavioral development have …
[HTML][HTML] Transcriptomic effects of paternal cocaine-seeking on the reward circuitry of male offspring
N Huang, J Cui, G Fan, T Pan, K Han, K Xu… - Translational …, 2024 - nature.com
It has been previously established that paternal development of a strong incentive
motivation for cocaine can predispose offspring to develop high cocaine-seeking behavior …
motivation for cocaine can predispose offspring to develop high cocaine-seeking behavior …
Paternal cocaine in mice alters social behavior and brain oxytocin receptor density in first generation offspring
It is well established that the damaging effects of drugs of abuse, such as cocaine, can
extend beyond the user to their offspring. While most preclinical models of the generational …
extend beyond the user to their offspring. While most preclinical models of the generational …
Impaired cocaine‐induced behavioral plasticity in the male offspring of cocaine‐experienced sires
ME Wimmer, FM Vassoler, SL White… - European Journal of …, 2019 - Wiley Online Library
Our previous work indicated that male, but not female, offspring of cocaine‐experienced
sires display blunted cocaine self‐administration. We extended this line of investigation to …
sires display blunted cocaine self‐administration. We extended this line of investigation to …
Reduced cocaine reinforcement in the male offspring of cocaine-experienced sires.
RC Pierce, FM Vassoler - Neuropharmacology, 2014 - nature.com
Mounting evidence suggests that parental ingestion of abused drugs influences the
physiology and behavior of future generations in the absence of prenatal exposure …
physiology and behavior of future generations in the absence of prenatal exposure …
[HTML][HTML] Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour
Q Le, B Yan, X Yu, Y Li, H Song, H Zhu, W Hou… - Nature …, 2017 - nature.com
Liability to develop drug addiction is heritable, but the precise contribution of non-Mendelian
factors is not well understood. Here we separate male rats into addiction-like and non …
factors is not well understood. Here we separate male rats into addiction-like and non …
[PDF][PDF] Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in a panel of inbred and recombinant inbred mice
To identify addiction genes, we evaluate intravenous self-administration of cocaine or saline
in 84 inbred and recombinant inbred mouse strains over 10 days. We integrate the behavior …
in 84 inbred and recombinant inbred mouse strains over 10 days. We integrate the behavior …
[HTML][HTML] Paternal cocaine-seeking motivation defines offspring's vulnerability to addiction by down-regulating GABAergic GABRG3 in the ventral tegmental area
J Cui, N Huang, G Fan, T Pan, K Han, C Jiang… - Translational …, 2024 - nature.com
Epidemiological investigations indicate that parental drug abuse experiences significantly
influenced the addiction vulnerability of offspring. Studies using animal models have shown …
influenced the addiction vulnerability of offspring. Studies using animal models have shown …