Background Although age-related loss of chromosome Y (LOY) in normal hematopoietic
cells is a well-known phenomenon, the phenotypic consequences of LOY have been …

Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is
largely unexplained,. Furthermore, age-related loss of chromosome Y (LOY) is frequent in …

Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes
is associated with earlier mortality and morbidity from many diseases in men. LOY is the …

Loss of the Y chromosome (LoY) is frequently observed in somatic cells of elderly men.
However, LoY is highly increased in tumor tissue and correlates with an overall worse …

Mosaic loss of the Y chromosome (mLOY) in peripheral leukocytes is a somatic event in
which a fraction of leukocytes have lost the entire Y chromosome. The frequency of mLOY …

Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …

Mosaic loss of chromosome Y (LOY) is the most common somatic genetic aberration and is
associated with increased risk for all-cause mortality, various forms of cancer and …

Background: Genomic instability is a significant hallmark of aging and has a major impact on
aging biology. Mosaic loss of chromosome Y (mLOY) in blood cells is a common …

Loss of the Y chromosome (LOY) is one of the most common somatic genomic alterations in
hematopoietic cells in men. However, due to the high prevalence of LOY as the sole …

Background There has been continuous debate as to whether Y chromosome loss is an age
related phenomenon or a cytogenetic marker indicating a malignant change. This study …