[HTML][HTML] Insulin resistance: from mechanisms to therapeutic strategies
SH Lee, SY Park, CS Choi - Diabetes & metabolism journal, 2022 - synapse.koreamed.org
Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …
[HTML][HTML] Mechanisms of insulin action and insulin resistance
MC Petersen, GI Shulman - Physiological reviews, 2018 - journals.physiology.org
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …
research into insulin action and resistance has issued. In the intervening century, some …
Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue
SC da Silva Rosa, N Nayak, AM Caymo… - Physiological …, 2020 - Wiley Online Library
Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
Muscle and adipose tissue insulin resistance: malady without mechanism?
DJ Fazakerley, JR Krycer, AL Kearney… - Journal of Lipid …, 2019 - ASBMB
Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …
cardiovascular disease. These disorders have dramatically increased in incidence with …
Defining the underlying defect in insulin action in type 2 diabetes
Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …
the past 50 years, elucidation of the insulin signalling network has provided important …
The aetiology and molecular landscape of insulin resistance
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
Insulin resistance: Review of the underlying molecular mechanisms
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …
Mechanisms for insulin resistance: common threads and missing links
VT Samuel, GI Shulman - Cell, 2012 - cell.com
Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …
Mechanisms of insulin resistance in humans and possible links with inflammation
DB Savage, KF Petersen, GI Shulman - Hypertension, 2005 - Am Heart Assoc
Insulin resistance is a major player in the pathogenesis of the metabolic syndrome and type
2 diabetes, and yet, the mechanisms responsible for it remain poorly understood. Magnetic …
2 diabetes, and yet, the mechanisms responsible for it remain poorly understood. Magnetic …
Pathophysiology of insulin resistance
G Sesti - Best practice & research Clinical endocrinology & …, 2006 - Elsevier
Insulin resistance is a feature of a number of clinical disorders, including type 2
diabetes/glucose intolerance, obesity, dyslipidaemia and hypertension clustering in the so …
diabetes/glucose intolerance, obesity, dyslipidaemia and hypertension clustering in the so …