[HTML][HTML] Computational and pharmacokinetics studies of 1, 3-dimethylbenzimidazolinone analogues of new proposed agent against Alzheimer's disease
Background Alzheimer's disease (AD) is a multifactorial disorder that gradually destroys
wisdom and memory skills. Currently, this disease can only be treated palliatively. However …
wisdom and memory skills. Currently, this disease can only be treated palliatively. However …
[HTML][HTML] QSAR, simulation techniques, and ADMET/pharmacokinetics assessment of a set of compounds that target MAO-B as anti-Alzheimer agent
Background Alzheimer's disease (AD), the most common cause of dementia in the elderly, is
a progressive neurodegenerative disorder that gradually affects cognitive function and …
a progressive neurodegenerative disorder that gradually affects cognitive function and …
[HTML][HTML] 2D QSAR, design, docking study and ADMET of some N-aryl derivatives concerning inhibitory activity against Alzheimer disease
Background Alzheimer disease (AD) is an ailment that disturbs mainly people of old age.
The fundamental remedial way to deal with AD depends on the utilization of AChEI. The …
The fundamental remedial way to deal with AD depends on the utilization of AChEI. The …
[HTML][HTML] QSAR application of natural therapeutics inhibitors against Alzheimer's disease through in-silico virtual-screening, docking-simulation, molecular dynamics …
Alzheimer's disease (AD) is a brain disorder that is known to be one of the deadliest
diseases affecting humanity, especially adults from the age of sixty (60) years and above. It …
diseases affecting humanity, especially adults from the age of sixty (60) years and above. It …
[HTML][HTML] Structure-based drug design of novel piperazine containing hydrazone derivatives as potent Alzheimer inhibitors: molecular docking and drug kinetics …
Alzheimer's disease (AD) is a neurodegenerative disorder that causes dementia and
cognitive impairment in the elderly. The exact mechanism of the disease is still unknown …
cognitive impairment in the elderly. The exact mechanism of the disease is still unknown …
[HTML][HTML] Biologically potent benzimidazole-based-substituted benzaldehyde derivatives as potent inhibitors for alzheimer's disease along with molecular docking study
Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted
benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and …
benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and …
QSAR, Molecular Docking, Dynamic Simulation and Kinetic Study of Monoamine Oxidase B Inhibitors as Anti-Alzheimer Agent
Alzheimer's disease (AD) is a neurological ailment that affects the elderly, causes dementia
and cognitive impairment. The disease's specific mechanism has yet to be uncovered. New …
and cognitive impairment. The disease's specific mechanism has yet to be uncovered. New …
[HTML][HTML] In silico docking and comparative ADMET profile of different glycogen synthase kinase 3 beta inhibitors as the potential leads for the development of anti …
M Prajapat, P Sarma, N Shekhar, H Kaur… - Journal of Advanced …, 2020 - journals.lww.com
Glycogen synthase kinase 3 beta (GSK3 β) plays a key role in pathologic hyper
phosphorylation of tau and plays an important role in the pathogenesis of Alzheimer's …
phosphorylation of tau and plays an important role in the pathogenesis of Alzheimer's …
[HTML][HTML] Design of a new potent Alzheimer's disease inhibitor based on QSAR, molecular docking and molecular dynamics investigations
A series of 32 molecules derived from 7-prenyloxy-2, 3-dihydroflavanone and 5‑hydroxy-7-
prenyloxy-2, 3-dihydro-flavanone possessing an inhibitory activity against the …
prenyloxy-2, 3-dihydro-flavanone possessing an inhibitory activity against the …
Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease
P Meena, V Nemaysh, M Khatri, A Manral… - Bioorganic & medicinal …, 2015 - Elsevier
Abstract Development of Multi-Target Directed Ligands (MTDLs) has emerged as a
promising approach for targeting complex etiology of Alzheimer's disease (AD). Following …
promising approach for targeting complex etiology of Alzheimer's disease (AD). Following …