Inhibition of caspase-2 translation by the mRNA binding protein HuR: a novel path of therapy resistance in colon carcinoma cells?
W Eberhardt, U Nasrullah, K Haeussler - Cells, 2019 - mdpi.com
An increased expression and cytoplasmic abundance of the ubiquitous RNA binding protein
human antigen R (HuR) is critically implicated in the dysregulated control of post …
human antigen R (HuR) is critically implicated in the dysregulated control of post …
Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2
A Badawi, S Hehlgans, J Pfeilschifter, F Rödel… - Cancer letters, 2017 - Elsevier
Increased abundance of the mRNA-binding protein human antigen R (HuR) is a
characteristic feature of many cancers and frequently associated with a high grade …
characteristic feature of many cancers and frequently associated with a high grade …
[HTML][HTML] Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells
A Badawi, A Biyanee, U Nasrullah, S Winslow… - Oncotarget, 2018 - ncbi.nlm.nih.gov
HuR plays an important role in tumor cell survival mainly through posttranscriptional
upregulation of prominent anti-apoptotic genes. In addition, HuR can inhibit the translation of …
upregulation of prominent anti-apoptotic genes. In addition, HuR can inhibit the translation of …
Posttranscriptional orchestration of an anti-apoptotic program by HuR
The RNA-binding protein HuR can stabilize and/or regulate the translation of target mRNAs,
thereby affecting the cellular responses to immune, proliferative, and damaging agents …
thereby affecting the cellular responses to immune, proliferative, and damaging agents …
Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L
C Winkler, A Doller, G Imre, A Badawi, T Schmid… - Cell death & …, 2014 - nature.com
Caspase-2 represents the most conserved member of the caspase family, which exhibits
features of both initiator and effector caspases. Using ribonucleoprotein (RNP) …
features of both initiator and effector caspases. Using ribonucleoprotein (RNP) …
Role of the RNA-binding protein HuR in apoptosis and apoptosome function
Y Kuwano, IE Gallouzi, M Gorospe - … : an up-and-coming therapeutical tool, 2010 - Springer
In response to damaging agents, cells alter gene expression patterns through transcriptional
and post-transcriptional mechanisms. Among the major post-transcriptional regulators of …
and post-transcriptional mechanisms. Among the major post-transcriptional regulators of …
Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells
Background HuR, an RNA binding protein involved in the post-transcriptional regulation of a
wide spectrum of mRNAs, has been demonstrated to be a determinant of carcinogenesis …
wide spectrum of mRNAs, has been demonstrated to be a determinant of carcinogenesis …
Targeting the RNA-binding protein HuR in cancer
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
The RNA-binding protein HuR in human cancer: A friend or foe?
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …
elements present in mRNAs whose stability and translation are subject to regulation. The …
Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma
H Janakiraman, RP House, S Talwar, SM Courtney… - Oncogene, 2017 - nature.com
A well-studied RNA-binding protein Hu Antigen-R (HuR), controls post-transcriptional gene
regulation and undergoes stress-activated caspase-3 dependent cleavage in cancer cells …
regulation and undergoes stress-activated caspase-3 dependent cleavage in cancer cells …