Endothelin-1 (ET-1) is a potent vasoconstrictive peptide produced by endothelial cells of
blood vessels. This peptide has quite a unique structure and pharmacological properties. ET …

Endothelin (ET) is a potent vasoconstrictive peptide initially found in the conditioned medium
of cultured endothelial cells (1). It comprises 21 amino acid residues including four cysteine …

Endothelin-1 is a recently discovered peptide mainly released from endothelial cells.
Hypoxia and ischemia as well as numerous factors such as angiotensin 11, thrombin and …

The endothelium synthesizes and releases paracrine hormones that regulate the contraction
and physiology of vascular smooth muscle cells. 1-3 In addition to the well-described …

Endothelin is a peptide with potent biologic effects in vascular and nonvascular cells. Its
effects are mediated by two receptors, ETA and ETB, and possibly also by a third receptor …

Summary The endothelins (ET-1, 2, and 3) constitute a family of 21 amino-acid peptides with
potent biological activities. They are synthesized in several tissues, including the vascular …

In 1988, Yanagisawa et al. reported the presence of a potent peptide from the supernatant of
porcine endothelial cells. This was later named endothelin‐1 (ET‐1) and was found to …

The normal functional state of the vasculature and the events leading to the development of
significant arterial disease involve the interaction of important vasoactive substances, which …

To investigate the physiological roles of endothelin (ET) in the brain and pituitary gland, the
presence of immunoreactive (ir) ET and ET receptors was studied by radioimmunoassay …

Endothelin-1 (ET-1) is a potent vasoconstrictor and pressor agent with a prolonged action in
animal preparations. We have investigated the vascular pharmacology of ET-1 in healthy …