Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns

J Cai, XL Zhao, AW Liu, H Nian, SH Zhang - Phytomedicine, 2011 - Elsevier
Apigenin, a common plant flavonoid, has been shown to possess anti-tumor properties;
however, the underlying molecular mechanisms are still not completely understood. In the …

[HTML][HTML] Apigenin inhibits the growth of hepatocellular carcinoma cells by affecting the expression of microRNA transcriptome

SM Wang, PW Yang, XJ Feng, YW Zhu, FJ Qiu… - Frontiers in …, 2021 - frontiersin.org
Background Apigenin, as a natural flavonoid, has low intrinsic toxicity and has potential
pharmacological effects against hepatocellular carcinoma (HCC). However, the molecular …

Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells

LC Chiang, LT Ng, IC Lin, PL Kuo, CC Lin - Cancer letters, 2006 - Elsevier
Apigenin, a common dietary flavonoid abundantly present in fruits and vegetables, is
believed to possess preventive and therapeutic potential against cancers. In this study, the …

Apigenin, a flavonoid constituent derived from P. villosa, inhibits hepatocellular carcinoma cell growth by CyclinD1/CDK4 regulation via p38 MAPK-p21 signaling

Y Li, X Cheng, C Chen, W Huijuan, H Zhao… - … -Research and Practice, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide. Apigenin
was widely used in HCC treatment; however, the detailed mechanisms have not been …

H19-Wnt/β-catenin regulatory axis mediates the suppressive effects of apigenin on tumor growth in hepatocellular carcinoma

F Pan, YB Zheng, CJ Shi, F Zhang, J Zhang… - European Journal of …, 2021 - Elsevier
Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. However, the effective pharmacological approaches remain scanty in clinical …

[HTML][HTML] Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

J Yang, C Pi, G Wang - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Apigenin is a dietary flavonoid with known antioxidant and antitumor effects against several
types of cancers by promoting cell death and inducing cell cycle arrest. Apigenin also …

[HTML][HTML] Apigenin inhibits renal cell carcinoma cell proliferation

S Meng, Y Zhu, JF Li, X Wang, Z Liang, SQ Li, X Xu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Apigenin, a natural flavonoid found in vegetables and fruits, has antitumor activity in several
cancer types. The present study evaluated the effects and mechanism of action of apigenin …

Deciphering the modulatory role of apigenin targeting oncogenic pathways in human cancers

P Pandey, F Khan, TK Upadhyay - Chemical Biology & Drug …, 2023 - Wiley Online Library
Cancer is a complicated malignancy controlled by numerous intrinsic and extrinsic
pathways. There has been a significant increase in interest in recent years in the elucidation …

[HTML][HTML] Apigenin suppresses the growth of colorectal cancer xenografts via phosphorylation and up-regulated FADD expression

QR Wang, XQ Yao, G Wen, Q Fan, YJ Li… - Oncology …, 2011 - spandidos-publications.com
Apigenin is a flavonoid belonging to the flavone structural class. It has been implicated as a
chemopreventive agent against prostate and breast cancers. However, to the best of our …

Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis

AM Gao, XY Zhang, JN Hu, ZP Ke - Chemico-Biological Interactions, 2018 - Elsevier
Chemo-resistance is a serious obstacle for successful treatment of cancer. Apigenin, a
dietary flavonoid, has been reported as an anticancer drug in various malignant cancers …